TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo - Wikidata - awgldk - TriplyDB

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

http://www.wikidata.org/entity/Q24606587

about

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1 A quantitative telomeric chromatin isolation protocol identifies different telomeric states Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization The genetics of dyskeratosis congenita Finding the end: recruitment of telomerase to telomeres Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions It all comes together at the ends: telomerase structure, function, and biogenesis Multiple facets of TPP1 in telomere maintenance RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7 Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.Inhibition of telomerase recruitment and cancer cell death Identification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.Telomere protection by TPP1/POT1 requires tethering to TIN2 SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin.Human telomeric proteins occupy selective interstitial sites.POT1-TPP1 regulates telomeric overhang structural dynamics.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.A Cajal body-independent pathway for telomerase trafficking in mice.The role of telomeres and telomerase in cancer research.Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.Human CST promotes telomere duplex replication and general replication restart after fork stalling.Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.Telomere maintenance mechanisms in cancer: clinical implications Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA.Functional characterization of the TERRA transcriptome at damaged telomeres.Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase.

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P2860

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

http://www.wikidata.org/entity/Q24606587

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@ast

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@en

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@nl

type

label

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@ast

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@en

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@nl

prefLabel

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@ast

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@en

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@nl

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P1433

Molecular and Cellular Biology

P1476

TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

@en

P2093

Brad Culp

http://www.w3.org/2001/XMLSchema#string

Eladio Abreu

http://www.w3.org/2001/XMLSchema#string

Elena Aritonovska

http://www.w3.org/2001/XMLSchema#string

Joachim Lingner

http://www.w3.org/2001/XMLSchema#string

Michael P Terns

http://www.w3.org/2001/XMLSchema#string

Patrick Reichenbach

http://www.w3.org/2001/XMLSchema#string

Rebecca M Terns

http://www.w3.org/2001/XMLSchema#string

P2860

Human telomerase contains two cooperating telomerase RNA molecules.

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

The POT1-TPP1 telomere complex is a telomerase processivity factor

PTOP interacts with POT1 and regulates its localization to telomeres

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

POT1 as a terminal transducer of TRF1 telomere length control

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

P304

2971-82

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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1100534

http://www.w3.org/2001/XMLSchema#string

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10.1128/MCB.00240-10

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P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

30

http://www.w3.org/2001/XMLSchema#string

P50

Gael Cristofari

P577

2010-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20404094

http://www.w3.org/2001/XMLSchema#string

P921

protein localization to chromosome, telomeric region

TERF1 interacting nuclear factor 2

Tripeptidyl peptidase 1

P932

2876666

http://www.w3.org/2001/XMLSchema#string