Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen.
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DNA helicase activity of SV40 large tumor antigenStructural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase -PrimaseSimian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factorsThe replication protein A binding site in simian virus 40 (SV40) T antigen and its role in the initial steps of SV40 DNA replication.Method to identify genomic targets of DNA binding proteins.Different regions of primase subunit p48 control mouse polyomavirus and simian virus 40 DNA replication in vitro.Simian virus 40 large-T-antigen-specific rejection of mKSA tumor cells in BALB/c mice is critically dependent on both strictly tumor-associated, tumor-specific CD8(+) cytotoxic T lymphocytes and CD4(+) T helper cellsA deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity.Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoA specific docking site for DNA polymerase {alpha}-primase on the SV40 helicase is required for viral primosome activity, but helicase activity is dispensableSV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival.The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain.The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen.Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells.Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens.The p53 complex from monkey cells modulates the biochemical activities of simian virus 40 large T antigenMutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo.Simian virus 40 DNA replication correlates with expression of a particular subclass of T antigen in a human glial cell lineFine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants.Alterations in the structure of new and old forms of simian virus 40 large T antigen (T) defined by age-dependent epitope changes: new T is the same as ATPase-active T.Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells.Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replicationFree and viral chromosome-bound simian virus 40 T antigen: changes in reactivity of specific antigenic determinants during lytic infectionExpression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells.Functional role of BK virus tumor antigens in transformationCharacterization of simian virus 40 large T antigen by using different monoclonal antibodies: T-p53 complexes are preferentially ATPase active and adenylylated.Owl monkey astrocytoma cells in culture spontaneously produce infectious JC virus which demonstrates altered biological properties.Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen.Modulation of p53 protein expression during cellular transformation with simian virus 40Characterization of monoclonal antibodies to human group B rotavirus and their use in an antigen detection enzyme-linked immunosorbent assay.Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.Large T-antigen double hexamers imaged at the simian virus 40 origin of replication.An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences.Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.Two synthetic Sp1-binding sites functionally substitute for the 21-base-pair repeat region to activate simian virus 40 growth in CV-1 cells.Altered phosphorylation of free and bound forms of monkey p53 and simian virus 40 large T antigen during lytic infection.
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Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Antigenic binding sites of mon ...... mian virus 40 large T antigen.
@en
type
label
Antigenic binding sites of mon ...... mian virus 40 large T antigen.
@en
prefLabel
Antigenic binding sites of mon ...... mian virus 40 large T antigen.
@en
P2093
P2860
P4510
P1433
P1476
Antigenic binding sites of mon ...... imian virus 40 large T antigen
@en
P2093
P2860
P304
P407
P577
1986-03-01T00:00:00Z