Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.
about
Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions.Effect of chemical modification and fragmentation on antigenic determinants of internal protein p30 and surface glycoprotein gp70 of type C retrovirusesMonoclonal antibodies specific for simian virus 40 tumor antigensT cells specific for alpha-beta interface regions of hemoglobin recognize the isolated subunit but not the tetramer and indicate presentation without processing.Antigenicity and native structure of globular proteins: low frequency of peptide reactive antibodies.Profile of the continuous antigenic regions on the extracellular part of the alpha chain of an acetylcholine receptor.Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxinProcessing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas.Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen.Expression of herpes simplex virus type 1 glycoprotein D deletion mutants in mammalian cellsLocalization of discontinuous epitopes of herpes simplex virus glycoprotein D: use of a nondenaturing ("native" gel) system of polyacrylamide gel electrophoresis coupled with Western blottingLocalization of epitopes of herpes simplex virus type 1 glycoprotein DLocalization and synthesis of an antigenic determinant of herpes simplex virus glycoprotein D that stimulates the production of neutralizing antibody.Molecular mechanisms of autoimmunity.Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin.Antigenicity of metallothionein.Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic driftCellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.Analysis of Escherichia coli colonization factor antigen I linear B-cell epitopes, as determined by primate responses, following protein sequence verification.Evaluation of the immunodiagnostic potential of a recombinant surface protein domain from Acanthamoeba castellanii.Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor.Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsinA novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the alpha-chain of human haemoglobin.Distance calculation of residues neighbouring to lysozyme antigenic sites. Site-neighbouring residues whose evolutionary substitution can modify the characteristics and binding energy of the sites.Conformation-dependent recognition of a protein by T cells requires presentation without processing.Nearest-neighbour analysis of myoglobin antigenic sites. Nearest-neighbour residues whose replacement can alter the environment of binding-site residue(s) and thus change their characteristics and binding capability.The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raiseT-cell recognition of human haemoglobin. Localization of the full T-cell recognition profile of the beta-chain by a comprehensive synthetic strategyT-cell recognition and antigen presentation of myoglobin. Protein recognition by site-specific T-cell clones is influenced by amino acid substitutions outside the site.Antigenic structure of human haemoglobin. Localization of the antigenic sites of the beta-chain in three host species by synthetic overlapping peptides representing the entire chainThe identification of epitopic sites in human alpha 1-proteinase inhibitor.Structurally inherent antigenic sites. Localization of the antigenic sites of the alpha-chain of human haemoglobin in three host species by a comprehensive synthetic approach.Haemoglobin binding with haptoglobin. Localization of the haptoglobin-binding site on the alpha-chain of human haemoglobin.Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.S-antigen: characterization of a pathogenic epitope which mediates experimental autoimmune uveitis and pinealitis in Lewis rats.Towards new vaccines.
P2860
Q30356755-22BD5F04-6E9C-4819-8F1C-D160CBAF1F39Q33915968-7112BBD3-2D6C-478F-B99C-6D5F39F3CD1AQ34249232-48849F2F-2DA7-409E-97F6-5AEE9AB0A351Q34301672-B84A8CD2-9A2C-42DC-A7CB-86754371407EQ34380503-15ADF2BC-F363-47FC-AE5C-315D1852166FQ34626778-58699D3D-E8D8-4274-8B48-E9FC68E413DCQ35585238-10ADB7A3-4A79-4724-99EB-72461E632FDBQ36217306-0A7A0329-8B36-4A49-BA62-3D28C96F80E6Q36257785-C09AC9F3-066F-4FB2-99E4-E980E6233A10Q36264118-CAF5F52F-426F-4537-8D2F-DDAB8567E924Q36521661-F6B2B67E-1353-44C1-8576-89543620BECCQ36860251-FE24DBD2-2122-4DAA-B259-8ED2F7AEC7F7Q36868575-FEE6D7EC-8169-4EE6-B3BD-926C341FA107Q36883752-BCD20417-EC2A-4AF7-BD43-741B0D9A1ABAQ36898378-78F1CAFD-FDDC-42C6-8130-FD0642895181Q36910738-2BE28160-05BB-4D34-8E0A-10400EED24C8Q37103773-679AD33D-ECBC-41C3-9BAC-EE3ED29DD026Q37603300-E1E6E977-798F-426B-AC58-246F4FE55305Q37610017-B5823EC7-1B0E-45EC-8ACE-1F4FD62E9F56Q39814308-F5E6E2BC-54B8-4B9C-9312-0C6AF1406739Q40145588-4E431E36-1223-40BF-A550-FC2ACD8F5CD5Q40146762-76B865A2-2B9E-44AF-834F-BC584EDC9D56Q40609172-34D83747-213D-4833-B46C-C1A263ED73F3Q41481418-711AF479-A6DE-4426-A873-6A53C34EAE5EQ41772495-49D59684-3F5E-4E6D-AD84-D0C3E2D97FA6Q41814519-94C6D974-C5C7-42F7-A4A8-1681D46372A2Q41819543-258784B4-DE0A-40AE-8B8B-E2B595D1DEA2Q41839079-736CA2BE-B5E6-43C0-A500-4760B587E31DQ41865023-92DC6093-7815-4743-A3C3-3FBD880CDD65Q42097789-3A19DFD2-F667-4C6F-9D0D-1D05302DE450Q42100567-A0E178A1-FE77-4B58-AB28-A1D4B790A72CQ42727092-E4005F51-A06B-40FF-89D3-AADF622008BFQ42835733-6945C0D9-D135-44AB-9032-6EB4E05C0047Q42852936-12F2EE9A-E529-4D94-B38E-36F31746A46EQ42856587-2B95B8BA-CB8C-494F-A133-1E865B3F9E6DQ42874669-B6DBD004-3513-42A3-AEB5-C03F6CDCDE7AQ43245555-2CF5E58F-6AE7-48B2-80FD-1F67E867584EQ46601930-64D55E5C-E956-46E1-8F58-302CD8F343A0Q48218363-458D864C-DCD9-4C1B-986A-8CB804792DEFQ55137546-50022B2D-3086-49BA-AEF5-519878FF31C0
P2860
Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
Precise determination of the e ...... ept for protein binding sites.
@en
Precise determination of the e ...... ept for protein binding sites.
@nl
type
label
Precise determination of the e ...... ept for protein binding sites.
@en
Precise determination of the e ...... ept for protein binding sites.
@nl
prefLabel
Precise determination of the e ...... ept for protein binding sites.
@en
Precise determination of the e ...... ept for protein binding sites.
@nl
P1433
P1476
Precise determination of the e ...... ept for protein binding sites.
@en
P2093
P304
P356
10.1016/0161-5890(78)90126-8
P577
1978-12-01T00:00:00Z