Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage
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Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and diseaseThe Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective StrategiesMitochondrial Redox Signaling and Tumor ProgressionThe Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle FunctionAntioxidant responses and cellular adjustments to oxidative stressMechanisms of altered redox regulation in neurodegenerative diseases--focus on S--glutathionylationProtein-thiol oxidation and cell death: regulatory role of glutaredoxinsMitochondrial Redox Dysfunction and Environmental ExposuresGlutathione and mitochondriaProtein glutathionylation in cardiovascular diseasesMitochondrial oxidative stress in aging and healthspanTemporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.Redox regulation of mitochondrial functionScreening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compoundAging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulationGlutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions.Peptide-based antibodies against glutathione-binding domains suppress superoxide production mediated by mitochondrial complex I.BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosusMechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulationCysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage.Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart.A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusionCardiac mitochondria and reactive oxygen species generationGlutaredoxin 2 prevents H(2)O(2)-induced cell apoptosis by protecting complex I activity in the mitochondria.Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.Design and use of peptide-based antibodies decreasing superoxide production by mitochondrial complex I and complex II.NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in ratsQuantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model.Cysteine-mediated redox signaling: chemistry, biology, and tools for discoveryIncreased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-).Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation.Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity.Glutaredoxin AtGRXC2 catalyses inhibitory glutathionylation of Arabidopsis BRI1-associated receptor-like kinase 1 (BAK1) in vitro.Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.Selective inhibition of deactivated mitochondrial complex I by biguanidesRegulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system.Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism.C-Peptide reduces mitochondrial superoxide generation by restoring complex I activity in high glucose-exposed renal microvascular endothelial cells.
P2860
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P2860
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Complex I within oxidatively s ...... in decreasing oxidative damage
@en
type
label
Complex I within oxidatively s ...... in decreasing oxidative damage
@en
prefLabel
Complex I within oxidatively s ...... in decreasing oxidative damage
@en
P2093
P2860
P356
P1476
Complex I within oxidatively s ...... in decreasing oxidative damage
@en
P2093
Alan J Robinson
Ian M Fearnley
Raquel Requejo
Stephanie Brown
Thomas R Hurd
Tracy A Prime
P2860
P304
24801-24815
P356
10.1074/JBC.M803432200
P407
P577
2008-07-08T00:00:00Z