Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
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The hedgehog pathway in triple-negative breast cancerMiniaturized pre-clinical cancer models as research and diagnostic tools.Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer.Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.Constitutive activation of Gli2 impairs bone formation in postnatal growing miceThe osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles.Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclastsInhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cellsThe Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction.The Hedgehog pathway: role in cell differentiation, polarity and proliferationStudying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma.Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model.Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome.Targeting the tumour microenvironment in ovarian cancerCXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy.Targeting hedgehog signaling in cancer: research and clinical developments.Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer.Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis.The role of intratumoral and systemic IL-6 in breast cancer.Nonclassical hedgehog-GLI signaling and its clinical implications.Sonidegib: First Global Approval.Targeted Agents in Preclinical and Early Clinical Development for the Treatment of Cancer Bone Metastases.Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation.Emerging from their burrow: Hedgehog pathway inhibitors for cancer.TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment.Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers.Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis.The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells.Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axisHedgehog signaling mediates woven bone formation and vascularization during stress fracture healing.Non-mammalian models of multiple endocrine neoplasia type 2.Hallmarks of Bone Metastasis.Targeting the tumour stroma to improve cancer therapy.BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repairThe "Yin and Yang" of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
P2860
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P2860
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Hedgehog signaling inhibition ...... cts on tumor microenvironment.
@en
type
label
Hedgehog signaling inhibition ...... cts on tumor microenvironment.
@en
prefLabel
Hedgehog signaling inhibition ...... cts on tumor microenvironment.
@en
P2093
P2860
P1433
P1476
Hedgehog signaling inhibition ...... ects on tumor microenvironment
@en
P2093
David Piwnica-Worms
Emanuela Heller
Fanxin Long
Hongju Deng
Jingyu Xiang
Jochen Schneider
Julie L Prior
Katherine N Weilbaecher
Kyu-Sang Joeng
Leah Goldberg
P2860
P304
P356
10.1158/0008-5472.CAN-11-2681
P407
P50
P577
2011-12-20T00:00:00Z