Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926) - Wikidata - awgldk - TriplyDB

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

http://www.wikidata.org/entity/Q28248383

about

CD200-expressing human basal cell carcinoma cells initiate tumor growth Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors The Role of Hedgehog Signaling in Tumor Induced Bone Disease Lung cancer-initiating cells: a novel target for cancer therapy Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Hedgehog signaling inhibitors as anti-cancer agents in osteosarcoma Hedgehog signaling pathway in ovarian cancer Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity Systemic therapy options for unresectable and metastatic chordomas.Controlling destiny through chemistry: small-molecule regulators of cell fate.Advanced treatment for basal cell carcinomas.The benefits and challenges associated with the use of drug delivery systems in cancer therapy Experimental approaches for the treatment of malignant gliomas.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Enhancement of cyclopamine via conjugation with nonmetabolic sugars NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations.Medicinal history of North American Veratrum.A piperidine chiron for the Veratrum alkaloids.Tackling the cancer stem cells - what challenges do they pose?Targeting Gli transcription activation by small molecule suppresses tumor growth.The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.Clinical implications of hedgehog signaling pathway inhibitors The hedgehog/Gli signaling paradigm in prostate cancer Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells.Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors.Small molecule Hedgehog pathway antagonists.Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy.

P2860

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P2860

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

http://www.wikidata.org/entity/Q28248383

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@ast

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@en

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@nl

type

label

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@ast

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@en

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@nl

prefLabel

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@ast

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@en

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

@nl

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Journal of Medicinal Chemistry

P1476

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

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P2093

Alfredo C Castro

http://www.w3.org/2001/XMLSchema#string

André Lescarbeau

http://www.w3.org/2001/XMLSchema#string

Brian C Austad

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Caroline N Woodward

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Eddy Tan

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Grace Lin

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James Conley

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Jeanne Ferguson

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Jennifer Hoyt

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Jens R Sydor

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4400-18

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scholarly article

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1509172

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10.1021/JM900305Z

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14

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52

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2009-07-23T00:00:00Z

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19522463

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