A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C.
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RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifsNovel alternative splicing and nuclear localization of human RGS12 gene productsRGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesiclesRGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domainAlternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signalingRGS2/G0S8 is a selective inhibitor of Gqalpha functionInteraction between RGS7 and polycystinA regulator of G protein signaling, RGS3, inhibits gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretionRegulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.Gα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years laterHuman RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variantsIdentification of RGS2 and type V adenylyl cyclase interaction sitesMuscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3TSplicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphineReceptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cellsStructural Basis for the Selectivity of the RGS Protein, GAIP, for G i Family Members: IDENTIFICATION OF A SINGLE AMINO ACID DETERMINANT FOR SELECTIVE INTERACTION OF G i SUBUNITS WITH GAIPRGS expression in cancer: oncomining the cancer microarray data.Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteinsNon-canonical functions of RGS proteinsReconstituted slow muscarinic inhibition of neuronal (Ca(v)1.2c) L-type Ca2+ channelsMild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.Regulation of GPCR signaling in hypertension.The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity.Genetic Analyses of a Three Generation Family Segregating Hirschsprung Disease and Iris Heterochromia.RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons.Regulation of Smad-mediated gene transcription by RGS3.Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channelsRGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammationMolecular profiling of midbrain dopamine regions in cocaine overdose victimsRegulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function.Negative regulation of alpha2-adrenergic receptor-mediated Gi signalling by a novel pathway.Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.Persistent activation of Gsalpha through limited proteolysis by calpain.Regulators of G protein signaling (RGS) proteins constitutively activate Gbeta gamma-gated potassium channels.Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.Gene transfer of calcitonin gene-related peptide to cerebral arteries.Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo.Oxygen-dependent PAF receptor binding and intracellular signaling in ovine fetal pulmonary vascular smooth muscle.
P2860
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P2860
A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A truncated form of RGS3 negat ...... sphoinositide phospholipase C.
@en
type
label
A truncated form of RGS3 negat ...... sphoinositide phospholipase C.
@en
prefLabel
A truncated form of RGS3 negat ...... sphoinositide phospholipase C.
@en
P2860
P356
P1476
A truncated form of RGS3 negat ...... osphoinositide phospholipase C
@en
P2093
T K Chatterjee
P2860
P304
15481-15487
P356
10.1074/JBC.272.24.15481
P407
P50
P577
1997-06-01T00:00:00Z