An improved method for covalently conjugating morpholino oligomers to antitumor antibodies
about
Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORFPretargeted radioimmunotherapy for hematologic and other malignanciesTumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector.Adding a clearing agent to pretargeting does not lower the tumor accumulation of the effector as predicted.A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49.Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant modelSuccessful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue.90Y labeled phosphorodiamidate morpholino oligomer for pretargeting radiotherapy.Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice.Synthesis and evaluation of [18F]exendin (9-39) as a potential biomarker to measure pancreatic β-cell mass.A novel pretargeting method for measuring antibody internalization in tumor cells.Novel DNA Polymer for Amplification Pretargeting.Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody.Intraperitoneal injection is not always a suitable alternative to intravenous injection for radiotherapyAn experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effectorSelf-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery.A semiempirical model of tumor pretargeting.Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.Oligonucleotide conjugates for therapeutic applications.Pretargeting CWR22 prostate tumor in mice with MORF-B72.3 antibody and radiolabeled cMORF.Synthesis and in vitro characterization of a dendrimer-MORF conjugate for amplification pretargeting.Decoration of trastuzumab with short oligonucleotides: synthesis and detailed characterization.Use of Morpholino Oligomers for Pretargeting.In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system.
P2860
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P2860
An improved method for covalently conjugating morpholino oligomers to antitumor antibodies
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
An improved method for covalen ...... gomers to antitumor antibodies
@en
type
label
An improved method for covalen ...... gomers to antitumor antibodies
@en
prefLabel
An improved method for covalen ...... gomers to antitumor antibodies
@en
P2093
P2860
P356
P1476
An improved method for covalen ...... gomers to antitumor antibodies
@en
P2093
Donald Hnatowich
Guozheng Liu
Mary Rusckowski
Shuping Dou
Suresh Gupta
P2860
P304
P356
10.1021/BC060208V
P577
2007-03-27T00:00:00Z