Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. - Wikidata - awgldk - TriplyDB

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

http://www.wikidata.org/entity/Q36869970

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Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.eRapa restores a normal life span in a FAP mouse model.Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo.The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway.Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells.Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.Optimal therapy for desmoid tumors: current options and challenges for the future.mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.Targeted therapy of colorectal neoplasia with rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles.Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention.Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2.Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse.mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells Adaptations to chronic rapamycin in mice.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.Rapamycin, anti-aging, and avoiding the fate of Tithonus CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities.Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.

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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

http://www.wikidata.org/entity/Q36869970

description

2008 nî lūn-bûn

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2008年の論文

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2008年论文

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2008年论文

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name

Inhibition of the mTORC1 pathw ...... mortality in ApcDelta716 mice.

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Inhibition of the mTORC1 pathw ...... mortality in ApcDelta716 mice.

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Inhibition of the mTORC1 pathw ...... mortality in ApcDelta716 mice.

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Koji Aoki

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Makoto M Taketo

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Masahiro Aoki

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Teruaki Fujishita

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

Targeting HIF-1 for cancer therapy

TOR signaling in growth and metabolism

TSC2 mediates cellular energy response to control cell growth and survival

Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells

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