Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. - Wikidata - awgldk - TriplyDB

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.

http://www.wikidata.org/entity/Q33667595

about

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Mouse models of intestinal cancer Colorectal cancer models for novel drug discovery Rebuilding cancer metastasis in the mouse Animal models of colorectal cancer In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.Mouse models of colorectal cancer as preclinical models ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development Genotype directed therapy in murine mismatch repair deficient tumors In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide.A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments.Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.Mouse models of colorectal cancer.Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture An EGFR targeted PET imaging probe for the detection of colonic adenocarcinomas in the setting of colitis Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia.Animal models and therapeutic molecular targets of cancer: utility and limitations.The utility of Apc-mutant rats in modeling human colon cancer.Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.A cross-species analysis method to analyze animal models' similarity to human's disease state.Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.Clonal structure of carcinogen-induced intestinal tumors in mice Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras Multiscale analysis of the murine intestine for modeling human diseases.Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.Antiangiogenic Therapy Impedes Infiltration by CD4+ and CD8+ Cells Into an Early Colon Tumor K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.

P2860

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P2860

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.

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2010年の論文

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Development of a mouse model f ...... e in assessing drug treatment.

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Alexandra Kunin

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Kenneth E Hung

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Larissa Georgeon Richard

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Marco A Maricevich

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Michael P Richardson

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Raju Kucherlapati

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Roderick T Bronson

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Umar Mahmood

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Wei Y Chen

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P2860

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Cancer statistics, 2008

Lessons from hereditary colorectal cancer

Defining the role of mTOR in cancer

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

Ras, PI(3)K and mTOR signalling controls tumour cell growth

Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse.

Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.

Conditional mouse models of sporadic cancer.

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1565-1570

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