Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.
about
Energy disruptors: rising stars in anticancer therapy?Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolismEnergy and redox homeostasis in tumor cellsThe thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndromeSelenoproteins: molecular pathways and physiological roles.Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia.The thioredoxin system in neonatal lung diseaseReactive oxygen species in normal and tumor stem cells.The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogasterCombined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancerDisruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.Auranofin is a potent suppressor of osteosarcoma metastasis.Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation.GermLine Variation in Superoxide Dismutase-2 (SOD2) and Survival Outcomes After Radiation Therapy for Prostate Cancer: Results of a Test and Validation Set Analysis.Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice.Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2-Related Factor 2 Activation.Dual targeting of the thioredoxin and glutathione systems in cancer and HIV.Antioxidant enzyme inhibitor role of phosphine metal complexes in lung and leukemia cell lines.Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neuronsNaringin mitigates erythrocytes aging induced by paclitaxel: an in vitro study.Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer.Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism.Aldo-Keto Reductases Mediated Cytotoxicity of 2-Deoxyglucose: A Novel Anticancer Mechanism.
P2860
Q26771300-730A2021-064E-496E-BA44-5948400B3471Q28484655-FA4CF457-5BEE-4D92-A356-4F3CE5BAA91FQ28728744-0EF58756-FDE0-4E0B-AB86-462247A58EE6Q33632775-4A6D1B5B-8243-40A2-A2C3-DCEF3DCA59F8Q33913069-B1A70DE0-133F-4D12-88F1-F97ECEB71B14Q34231446-AEC96CEE-8E94-4AE8-A749-E37212B3F354Q34240142-52F11DE0-A7F9-4DBB-A800-93C088959847Q34370090-A1CD1E34-6C8D-4487-B669-8A25F83A96FFQ34392752-0BE07173-751B-47DF-803D-A1E3A430D0E0Q34789370-78B728FC-0E6A-428C-A4ED-FD67176A21C7Q35024486-D6676BDD-A001-4FF7-A381-2B6022BBE1EFQ35818332-EAFEF433-97A4-4A9A-A0D0-46F3F19E5EE8Q36447023-C270A435-147E-4A7E-AD29-6BC9683A8015Q36729542-422AA701-A618-4831-A5B6-D06AD7F040D5Q36771950-918D6A65-E84D-4EB0-A0E0-E9E109068634Q37147096-895632BA-F82D-4682-BB6B-19B2E2ADF75DQ37287365-1FB1DE67-48BC-477C-A5FB-AEF774FC2B3DQ37391555-304A1D04-704A-40C1-8258-33A3FD38D780Q38645501-128FB21C-8655-4E9B-B81B-E863D31652F9Q38738485-08D2E72B-3ECF-4966-AAEE-60C868DADB03Q38743262-C9176460-7ACA-4A0E-B861-4A4ED8A8F061Q38777415-BD467FD1-84D8-456F-B239-9B5614AC184FQ38823023-2D0FE296-4E89-4006-A041-E15BD6201878Q38917659-17BA7874-BC1C-4D7F-B1A5-206B0472E2F0Q41883328-2D5F6A29-7FED-47BB-BC6A-51058B11DE37Q44411204-1D7E27A5-FB27-4CF2-8BEA-3C2A2711ED92Q46271330-1CEF03AC-258B-4CDB-8C61-8B56982ABA22Q48535054-9E3C6490-44AA-4BF7-A1E3-A99228E211B5Q52607803-E21A7654-CDEC-4BF0-ABF0-6A9C5B8F94F2
P2860
Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Simultaneous inhibition of glu ...... killing via oxidative stress.
@en
type
label
Simultaneous inhibition of glu ...... killing via oxidative stress.
@en
prefLabel
Simultaneous inhibition of glu ...... killing via oxidative stress.
@en
P2093
P2860
P1476
Simultaneous inhibition of glu ...... l killing via oxidative stress
@en
P2093
David Gius
David M Mattson
Kranti A Mapuskar
Peter M Scarbrough
Walter H Watson
P2860
P304
P356
10.1016/J.FREERADBIOMED.2011.10.493
P577
2011-11-04T00:00:00Z