Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.
about
Phase I study of BIIB028, a selective heat shock protein 90 inhibitor, in patients with refractory metastatic or locally advanced solid tumors.Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAGCelastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptorsInduced protein degradation: an emerging drug discovery paradigm.Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.Hsp90 molecular chaperone inhibitors: are we there yet?The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.Involvement of calcium-mediated reactive oxygen species in inductive GRP78 expression by geldanamycin in 9L rat brain tumor cellsThe role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.BIIB021: A novel inhibitor to heat shock protein 90-addicted oncology.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.
P2860
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P2860
Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@ast
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@en
type
label
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@ast
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@en
prefLabel
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@ast
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@en
P2093
P2860
P1476
Reactive oxygen species mediat ...... geldanamycin and its analogs.
@en
P2093
Fuminori Hyodo
Hisanari Ishii
James B Mitchell
Murali C Krishna
Sara Goldstein
Uri Samuni
Yuval Samuni
P2860
P304
P356
10.1016/J.FREERADBIOMED.2010.03.001
P577
2010-03-06T00:00:00Z