5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.
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targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisSynthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomographyBiochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine.Mechanistic analysis of Mycobacterium tuberculosis Rv1347c, a lysine Nepsilon-acyltransferase involved in mycobactin biosynthesisSynthesis and cytotoxic activity of pentacyclic triterpenoid sulfamates.Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.Deciphering the Structural Requirements of Nucleoside Bisubstrate Analogues for Inhibition of MbtA in Mycobacterium tuberculosis: A FB-QSAR Study and Combinatorial Library Generation for Identifying Potential Hits.Targeting iron assimilation to develop new antibacterials.Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosisReaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.Iron trafficking as an antimicrobial targetAryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis.Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosisSelf-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.Nucleoside analogs and tuberculosis: new weapons against an old enemy.Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.Models for antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines.A continuous kinetic assay for adenylation enzyme activity and inhibition.Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.Probing the structure of Mycobacterium tuberculosis MbtA: model validation using molecular dynamics simulations and docking studies.A Multiple-Labeling Strategy for Nonribosomal Peptide Synthetases Using Active-Site-Directed Proteomic Probes for Adenylation Domains.Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.
P2860
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P2860
5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
5'-O-[(N-acyl)sulfamoyl]adenos ...... osynthesis of the mycobactins.
@en
type
label
5'-O-[(N-acyl)sulfamoyl]adenos ...... osynthesis of the mycobactins.
@en
prefLabel
5'-O-[(N-acyl)sulfamoyl]adenos ...... osynthesis of the mycobactins.
@en
P2093
P2860
P356
P1476
5'-O-[(N-acyl)sulfamoyl]adenos ...... osynthesis of the mycobactins.
@en
P2093
Amol Gupte
Chunhua Qiao
Courtney C Aldrich
Daniel J Wilson
Eric M Bennett
Helena I Boshoff
Ravindranadh V Somu
P2860
P304
P356
10.1021/JM070905O
P407
P577
2007-10-30T00:00:00Z