Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
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Identification of the Mycobacterium tuberculosis SUF machinery as the exclusive mycobacterial system of [Fe-S] cluster assembly: evidence for its implication in the pathogen's survival.Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domainTackling tuberculosis: Insights from an international TB Summit in LondonInhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malariaGenetics and assembly line enzymology of siderophore biosynthesis in bacteria.Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groups.Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosisStereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis.Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-15'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.Amino acid variability in the peptide composition of a suite of amphiphilic peptide siderophores from an open ocean Vibrio species.Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosisUtilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents.Reactions of N-benzyloxycarbamate derivatives with stabilized carbon nucleophiles: a new synthetic approach to polyhydroxamic acids and other hydroxamate-containing mixed ligand systemsFerric stability constants of representative marine siderophores: marinobactins, aquachelins, and petrobactin.Siderophores as molecular tools in medical and environmental applications.Synthesis of deuterium-labelled 5'-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d(4)) as an internal standard for quantitation of Sal-AMS.Total synthesis and biological evaluation of transvalencin Z.Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905.Synthesis of Transition-State Inhibitors of Chorismate Utilizing Enzymes from Bromobenzene cis-1,2-Dihydrodiol.
P2860
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P2860
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@ast
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@en
type
label
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@ast
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@en
prefLabel
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@ast
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@en
P2093
P356
P1476
Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications.
@en
P2093
P304
P356
10.1039/A809397K
P577
2000-02-01T00:00:00Z