Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.
about
Human Ku70/80 interacts directly with hTR, the RNA component of human telomeraseDeletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndromeHuman telomerase and its regulationHuman Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicingPolymerization defects within human telomerase are distinct from telomerase RNA and TEP1 bindingRetinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiationTelomere shortening and apoptosis in telomerase-inhibited human tumor cellsMDM2 negatively regulates the human telomerase RNA gene promoterThe differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomeraseXenoantigen, an alphaGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line.CTCF binds the proximal exonic region of hTERT and inhibits its transcription.Strict control of telomerase activation using Cre-mediated inversion.Reactivation of telomerase in cancerInsertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome MaintenanceMolecular interactions between telomerase and the tumor suppressor protein p53 in vitroTelomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivoTranscriptional regulation of telomerase activity: roles of the the Ets transcription factor familyDown-regulation of telomerase activity in malignant lymphomas by radiation and chemotherapeutic agentsIncreased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.Insights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomesExclusion of exon 2 is a common mRNA splice variant of primate telomerase reverse transcriptasesTelomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications.Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutantsA mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complexTetrahymena proteins p80 and p95 are not core telomerase components.Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.mRNA quantification and clinical evaluation of telomerase reverse transcriptase subunit (hTERT) in intracranial tumours of patients in the island of Crete.Natural and pharmacological regulation of telomeraseThe human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.Telomerized presenescent osteoblasts prevent bone mass loss in vivo.Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues.Multiple genetic variants in telomere pathway genes and breast cancer risk.The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.Role of telomerase in cellular proliferation and cancer.Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivoThe N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationAlternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.
P2860
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P2860
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Isolation of a candidate human ...... terns in different cell types.
@en
type
label
Isolation of a candidate human ...... terns in different cell types.
@en
prefLabel
Isolation of a candidate human ...... terns in different cell types.
@en
P2093
P2860
P50
P356
P1476
Isolation of a candidate human ...... tterns in different cell types
@en
P2093
P2860
P304
P356
10.1093/HMG/6.12.2011
P577
1997-11-01T00:00:00Z