Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway
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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative diseaseHCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA MiceTargeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic SteatohepatitisMolecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPKDiabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cellsA liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesA nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injuryTNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathwaySite-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivoc-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in miceIcam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation.Gene expression profiling and network analysis reveals lipid and steroid metabolism to be the most favored by TNFalpha in HepG2 cells.The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagyDiclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatmentActivation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells.Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death.JNK regulation of hepatic manifestations of the metabolic syndrome.Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cellsDiabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava.Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitorStathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injuryThe role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injurycAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinaseImprovement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death miceImpaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and ResuscitationRole of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty liversCytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver.Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1βHepatic apoptosis postburn is mediated by c-Jun N-terminal kinase 2.The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury.Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cellsDistinct functions of JNK and c-Jun in oxidant-induced hepatocyte death.Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice.
P2860
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P2860
Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Tumor necrosis factor-induced ...... he mitochondrial death pathway
@en
type
label
Tumor necrosis factor-induced ...... he mitochondrial death pathway
@en
prefLabel
Tumor necrosis factor-induced ...... he mitochondrial death pathway
@en
P2093
P2860
P356
P1476
Tumor necrosis factor-induced ...... he mitochondrial death pathway
@en
P2093
Jay H Lefkowitch
Mark J Czaja
Raina M Rigoli
Rajat Singh
Yongjun Wang
P2860
P304
15258-15267
P356
10.1074/JBC.M512953200
P407
P577
2006-03-29T00:00:00Z