Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.
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Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying MechanismsRevisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaIL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing StudyThe landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemiasRas pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibitionTwo decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation.Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.The evolution of clinical trials for infant acute lymphoblastic leukemia.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic TargetingChemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research.The development of targeted new agents to improve the outcome for children with leukemia.MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.Blinatumomab-induced lineage switch of B-ALL with t(4:11)(q21;q23) KMT2A/AFF1 into an aggressive AML: pre- and post-switch phenotypic, cytogenetic and molecular analysis.MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations.Towards personalized therapy in pediatric acute lymphoblastic leukemia: RAS mutations and prednisolone resistanceClinical and molecular epidemiology of neonatal leukemia in Brazil.Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia.RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia.Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia.MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo.Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol.New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update.De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.Relapsed infant MLL-rearranged acute lymphoblastic leukemia with additional genetic alterations.Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.Subclonality and prenatal origin ofRASmutations inKMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia
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P2860
Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Frequencies and prognostic imp ...... hoblastic leukemia in infants.
@en
type
label
Frequencies and prognostic imp ...... hoblastic leukemia in infants.
@en
prefLabel
Frequencies and prognostic imp ...... hoblastic leukemia in infants.
@en
P2093
P2860
P1433
P1476
Frequencies and prognostic imp ...... hoblastic leukemia in infants.
@en
P2093
Eddy H J van Roon
Emma M C Driessen
Jill A P Spijkers-Hagelstein
Maria Grazia Valsecchi
Paola de Lorenzo
Pauline Schneider
Ronald W Stam
P2860
P304
P356
10.3324/HAEMATOL.2012.067983
P50
P577
2013-02-12T00:00:00Z