H3K79 methylation profiles define murine and human MLL-AF4 leukemias. - Wikidata - awgldk - TriplyDB

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

http://www.wikidata.org/entity/Q36991857

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CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The many faces of histone H3K79 methylation Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia The complexity of epigenetic diseases Epigenomics of leukemia: from mechanisms to therapeutic applications Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Chromatin dynamics during cellular reprogramming Structural Biology of Human H3K9 Methyltransferases Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies Potent inhibition of DOT1L as treatment of MLL-fusion leukemia Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.Epigenetics in Cancer: A Hematological Perspective Misguided transcriptional elongation causes mixed lineage leukemia Human ALKBH4 interacts with proteins associated with transcription Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia EPITRANS: a database that integrates epigenome and transcriptome data Predicting expression: the complementary power of histone modification and transcription factor binding data.Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.Murine models of acute leukemia: important tools in current pediatric leukemia research.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.

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P2860

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

http://www.wikidata.org/entity/Q36991857

description

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

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J.CCR.2008.10.001

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

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Amit U Sinha

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Jeffery L Kutok

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Joerg Faber

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Jonathan Jesneck

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Lewis B Silverman

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Scott A Armstrong

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Sridhar Vempati

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Xiaobo Xia

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Zhaohui Feng

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P2860

Global and Hox-specific roles for the MLL1 methyltransferase

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

hDOT1L links histone methylation to leukemogenesis.

MLL targets SET domain methyltransferase activity to Hox gene promoters

A chromatin landmark and transcription initiation at most promoters in human cells

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

Inducible gene targeting in mice

MLL translocations, histone modifications and leukaemia stem-cell development

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5

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Madeleine Lemieux

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Adrian P Bracken

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23444862

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2591932

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