Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules
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Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortionStructure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylationA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationNeurodegeneration and microtubule dynamics: death by a thousand cutsCell cycle progression by the repression of primary cilia formation in proliferating cellsIdentification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasisMolecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.Specific in vivo labeling of tyrosinated α-tubulin and measurement of microtubule dynamics using a GFP tagged, cytoplasmically expressed recombinant antibodyCrystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N TerminusStructural and Functional Characterization of the α-Tubulin Acetyltransferase MEC-17Structural insights into HDAC6 tubulin deacetylation and its selective inhibitionAssembling a primary cilium.Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosisαTAT1 is the major α-tubulin acetyltransferase in miceAcetylated tubulin is essential for touch sensation in miceTgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondiiΑ-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesionThe doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neuronsEctopic A-lattice seams destabilize microtubules.Loss of MEC-17 leads to microtubule instability and axonal degeneration.Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.α-Tubulin acetylation from the inside outLuminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules.Tubulin acetylation: responsible enzymes, biological functions and human diseases.Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of cortiPost-translational modifications of tubulin: pathways to functional diversity of microtubules.α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration.Mechanical systems biology of C. elegans touch sensation.Writing and Reading the Tubulin Code.Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cellsEffects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structureThe tubulin repertoire of C. elegans sensory neurons and its context-dependent role in process outgrowth.The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.Dissecting the cellular functions of plant microtubules using mutant tubulins.Multifaceted roles of Furry proteins in invertebrates and vertebrates.Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production.
P2860
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P2860
Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Posttranslational acetylation ...... number in native microtubules
@en
type
label
Posttranslational acetylation ...... number in native microtubules
@en
prefLabel
Posttranslational acetylation ...... number in native microtubules
@en
P2093
P2860
P1433
P1476
Posttranslational acetylation ...... number in native microtubules
@en
P2093
Juan G Cueva
Kerwyn Casey Huang
P2860
P304
P356
10.1016/J.CUB.2012.05.012
P407
P577
2012-05-31T00:00:00Z