Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets.
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ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleedingThe ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrineInternational Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapyBlood cells: an historical account of the roles of purinergic signallingThe effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial diseaseHuman platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptorProtein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activationThe effect of a loading dose (300 mg) of clopidogrel on platelet function in patients with peripheral arterial diseaseAntiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cellsThe C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptorADP and platelets: the end of the beginningMolecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugsClopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritisCharacterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cellsThe P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human plateletsADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC.RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets.A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation.Purification, cloning, expression, and mechanism of action of a novel platelet aggregation inhibitor from the salivary gland of the blood-sucking bug, Rhodnius prolixus.Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change.P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortex.More pieces of the platelet activation puzzle slide into placeInherited platelet-based bleeding disorders.Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulenceNon-human primate model of poly-traumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans.Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entryDefective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null miceMutational analysis of residues important for ligand interaction with the human P2Y(12) receptor.Shaping the platelet response to vascular injury.ADP receptor antagonists as antiplatelet therapeutics.Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy.Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse plateletsADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors.Clopidogrel: interactions with the P2Y12 receptor and clinical relevance.Role of Purinergic Receptor Expression and Function for Reduced Responsiveness to Adenosine Diphosphate in Washed Human Platelets.(N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets.Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation.
P2860
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P2860
Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Molecular basis for ADP-induce ...... receptors on human platelets.
@en
type
label
Molecular basis for ADP-induce ...... receptors on human platelets.
@en
prefLabel
Molecular basis for ADP-induce ...... receptors on human platelets.
@en
P2093
P2860
P356
P1476
Molecular basis for ADP-induce ...... receptors on human platelets.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.4.2024
P407
P577
1998-01-01T00:00:00Z