Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.
about
Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold.Advances in the directed evolution of proteins.In vivo continuous directed evolutionReverse evolution leads to genotypic incompatibility despite functional and active site convergenceContingency and entrenchment in protein evolution under purifying selectionA Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live CellsStability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Causes of molecular convergence and parallelism in protein evolution.Bacteriophage-based synthetic biology for the study of infectious diseases.Evolutionary biochemistry: revealing the historical and physical causes of protein properties.A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutationsPeptide aptamers: development and applications.Deep mutational scanning: a new style of protein scienceHigh-speed multiparameter photophysical analyses of fluorophore libraries.Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants.Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.In vivo continuous evolution of genes and pathways in yeastDevelopment of potent in vivo mutagenesis plasmids with broad mutational spectra.Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.Negative selection and stringency modulation in phage-assisted continuous evolution.Dynamics and constraints of enzyme evolution.Epistasis in protein evolution.How mutational epistasis impairs predictability in protein evolution and designDirected evolution of genetic parts and circuits by compartmentalized partnered replication.Phage-assisted continuous evolution of proteases with altered substrate specificity.Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CAAlternative evolutionary histories in the sequence space of an ancient protein.Compensatory mutations and epistasis for protein function.Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme.Darwin Assembly: fast, efficient, multi-site bespoke mutagenesis.Evolution of a split RNA polymerase as a versatile biosensor platform.Applications of Normal Mode Analysis Methods in Computational Protein Design.Continuous directed evolution of proteins with improved soluble expressionDirected Evolution as a Probe of Rate Promoting Vibrations Introduced via Mutational Change
P2860
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P2860
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Experimental interrogation of ...... assisted continuous evolution.
@en
type
label
Experimental interrogation of ...... assisted continuous evolution.
@en
prefLabel
Experimental interrogation of ...... assisted continuous evolution.
@en
P2093
P2860
P356
P1476
Experimental interrogation of ...... assisted continuous evolution.
@en
P2093
Aaron M Leconte
Bryan C Dickinson
David R Liu
P2860
P304
P356
10.1073/PNAS.1220670110
P407
P577
2013-05-14T00:00:00Z