Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. - Wikidata - awgldk - TriplyDB

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

http://www.wikidata.org/entity/Q36907698

about

Targeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond.The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase.Targeting spleen tyrosine kinase-Bruton's tyrosine kinase axis for immunologically mediated glomerulonephritis.Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).Ibrutinib and novel BTK inhibitors in clinical development.Molecular abnormalities of the B cell in systemic lupus erythematosus are candidates for functional inhibition treatments.Quantitative structure-activity relationship study on BTK inhibitors by modified multivariate adaptive regression spline and CoMSIA methods.BTK Signaling in B Cell Differentiation and Autoimmunity.Ibrutinib-A double-edge sword in cancer and autoimmune disorders.Lupus nephritis and B-cell targeting therapy.A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers.The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer.Enhanced Bruton's Tyrosine Kinase Activity in Peripheral Blood B Lymphocytes From Patients With Autoimmune Disease.Novel Treatments in Lupus.An update on lupus animal models.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus.Bruton Tyrosine Kinase Inhibition Attenuates Liver Damage in a Mouse Warm Ischemia and Reperfusion Model.Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.Increased expression of Bruton's tyrosine kinase in peripheral blood is associated with lupus nephritis.Enhanced Expression of Bruton's Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis.Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia.

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Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

http://www.wikidata.org/entity/Q36907698

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

@zh

2012年论文

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name

Modulating proximal cell signa ...... organ disease in murine lupus.

@en

type

label

Modulating proximal cell signa ...... organ disease in murine lupus.

@en

prefLabel

Modulating proximal cell signa ...... organ disease in murine lupus.

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Arthritis Research and Therapy

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Modulating proximal cell signa ...... organ disease in murine lupus.

@en

P2093

Anna Bashmakov

http://www.w3.org/2001/XMLSchema#string

Anne B Satterthwaite

http://www.w3.org/2001/XMLSchema#string

Betty Y Chang

http://www.w3.org/2001/XMLSchema#string

Chandra Mohan

http://www.w3.org/2001/XMLSchema#string

Deena Sajitharan

http://www.w3.org/2001/XMLSchema#string

Jack Hutcheson

http://www.w3.org/2001/XMLSchema#string

Joseph J Buggy

http://www.w3.org/2001/XMLSchema#string

Kamala Vanarsa

http://www.w3.org/2001/XMLSchema#string

Simer Grewal

http://www.w3.org/2001/XMLSchema#string

Xin J Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells.

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.

The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints

Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

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scholarly article

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10.1186/AR4086

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6

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14

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2012-11-08T00:00:00Z

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233382843

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23136880

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