Sirtuins: critical regulators at the crossroads between cancer and aging.
about
Genealogy of an ancient protein family: the Sirtuins, a family of disordered membersSirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionDietary, metabolic, and potentially environmental modulation of the lysine acetylation machinerySIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activitySIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1Crystal structures of human SIRT3 displaying substrate-induced conformational changesSIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activitiesThe NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian controlSIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressSIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70Calorie restriction and the exercise of chromatinHistone H4 lysine 16 acetylation regulates cellular lifespanHDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory DiseasesSirtuin 1 and sirtuin 3: physiological modulators of metabolismSIRTain regulators of premature senescence and accelerated agingTrials with 'epigenetic' drugs: an updateSirtuin-dependent epigenetic regulation in the maintenance of genome integrityHigh SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinomaPotential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARĪ³ Expression and/or Its Transcriptional ActivitySirtuins in metabolism, DNA repair and cancerRegulation of epithelial-mesenchymal transition through epigenetic and post-translational modificationsLoss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective StudyThe tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylationSIRT3 and cancer: tumor promoter or suppressor?Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesisBiochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3Emerging Roles of SIRT1 in Cancer Drug ResistanceMetabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cellsRegulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylasesAntagonistic pleiotropy and p53.The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growthIn vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets.Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activityMaternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice.Human sirt-1: molecular modeling and structure-function relationships of an unordered protein.The hexosamine signaling pathway: O-GlcNAc cycling in feast or famineDiabetes mellitus: channeling care through cellular discoveryHow does SIRT1 affect metabolism, senescence and cancer?Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture.Circadian clocks and metabolism.
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Sirtuins: critical regulators at the crossroads between cancer and aging.
description
2007 nĆ® lÅ«n-bĆ»n
@nan
2007幓ć®č«ę
@ja
2007幓č«ę
@yue
2007幓č«ę
@zh-hant
2007幓č«ę
@zh-hk
2007幓č«ę
@zh-mo
2007幓č«ę
@zh-tw
2007幓č®ŗę
@wuu
2007幓č®ŗę
@zh
2007幓č®ŗę
@zh-cn
name
Sirtuins: critical regulators at the crossroads between cancer and aging.
@en
type
label
Sirtuins: critical regulators at the crossroads between cancer and aging.
@en
prefLabel
Sirtuins: critical regulators at the crossroads between cancer and aging.
@en
P2860
P356
P1433
P1476
Sirtuins: critical regulators at the crossroads between cancer and aging.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210616
P407
P577
2007-08-01T00:00:00Z
P5875
P6179
1001040123