Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
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Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciensImproved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies.Electrical Retrieval of Living Microorganisms from Cryopreserved Marine Sponges Using a Potential-Controlled ElectrodeModel-driven intracellular redox status modulation for increasing isobutanol production in Escherichia coli.Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.Comparative proteomic and metabolomic analysis of Streptomyces tsukubaensis reveals the metabolic mechanism of FK506 overproduction by feeding soybean oil.Genome-scale metabolic network reconstruction of Saccharopolyspora spinosa for spinosad production improvement.Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects.Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites.Integration of parallel 13 C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin.Transcriptomics-based strain optimization tool for designing secondary metabolite overproducing strains of Streptomyces coelicolor.Rational selection and engineering of exogenous principal sigma factor (σ(HrdB)) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus.Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2).Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism.The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production.Combining metabolomics and network analysis to improve tacrolimus production in Streptomyces tsukubaensis using different exogenous feedings.Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production.FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups
P2860
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P2860
Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Genome-scale metabolic network ...... r FK506 production improvement
@en
type
label
Genome-scale metabolic network ...... r FK506 production improvement
@en
prefLabel
Genome-scale metabolic network ...... r FK506 production improvement
@en
P2093
P2860
P356
P1476
Genome-scale metabolic network ...... r FK506 production improvement
@en
P2093
Jianping Wen
Menglei Xia
Shanshan Li
Xiaoqiang Jia
P2860
P2888
P356
10.1186/1475-2859-12-52
P577
2013-05-24T00:00:00Z
P5875
P6179
1051783859