FcgammaRIIB as a modulator of autoimmune disease susceptibility.
about
Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility proteinAntigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody.Generation of gene-engineered chimeric DNA molecules for specific therapy of autoimmune diseases.DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.Involvement of Fc receptors in disorders of the central nervous system.p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppressionSuppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19.Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus.PI3Ks in lymphocyte signaling and developmentHistorical overview of immunological tolerance.Making autoantibodies safeAntigen receptor signaling in the rheumatic diseasesB cells as therapeutic targets in SLE.Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.FcγRIIB: a modulator of cell activation and humoral tolerance.Assessments of antibody biodistribution.Annexin A1 as a target for managing murine pristane-induced systemic lupus erythematosus.Target silencing of disease-associated B-lymphocytes by chimeric molecules in SCID model of pristane-induced autoimmunity.Basophils contribute to pristane-induced Lupus-like nephritis model.Selective regulation of autoreactive B cells by FcgammaRIIB.Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb.Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor.The presence of FCGR2B promoter or transmembrane region variant alleles leads to reduced serum IL-6 levels in rheumatoid arthritis.
P2860
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P2860
FcgammaRIIB as a modulator of autoimmune disease susceptibility.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
FcgammaRIIB as a modulator of autoimmune disease susceptibility.
@en
type
label
FcgammaRIIB as a modulator of autoimmune disease susceptibility.
@en
prefLabel
FcgammaRIIB as a modulator of autoimmune disease susceptibility.
@en
P2093
P2860
P1433
P1476
FcgammaRIIB as a modulator of autoimmune disease susceptibility.
@en
P2093
Jonathan A Dean
Silvia Bolland
Tatyana Tarasenko
P2860
P304
P356
10.1080/08916930701464665
P577
2007-09-01T00:00:00Z