Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
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CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activityCalcium Flux across Plant Mitochondrial Membranes: Possible Molecular PlayersModulation of the matrix redox signaling by mitochondrial Ca(2.)The regulation of neuronal mitochondrial metabolism by calciumReliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriersExploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migrationLeucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporterNCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox stateLETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian ShepherdsThe Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the HeartAnalyses of Genotypes and Phenotypes of Ten Chinese Patients with Wolf-Hirschhorn Syndrome by Multiplex Ligation-dependent Probe Amplification and Array Comparative Genomic HybridizationChromosomal microarray testing identifies a 4p terminal region associated with seizures in Wolf-Hirschhorn syndrome.West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivationThe Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation.The destiny of Ca(2+) released by mitochondria.Unusual 4p16.3 deletions suggest an additional chromosome region for the Wolf-Hirschhorn syndrome-associated seizures disorder.Mitochondrial Ca(2+) Remodeling is a Prime Factor in Oncogenic Behavior.LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition.Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane.Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation.Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria.PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux.Pharmacological modulation of mitochondrial calcium homeostasis.LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum.
P2860
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P2860
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Letm1, the mitochondrial Ca2+/ ...... n in Wolf-Hirschhorn syndrome.
@en
type
label
Letm1, the mitochondrial Ca2+/ ...... n in Wolf-Hirschhorn syndrome.
@en
prefLabel
Letm1, the mitochondrial Ca2+/ ...... n in Wolf-Hirschhorn syndrome.
@en
P2860
P356
P1476
Letm1, the mitochondrial Ca2+/ ...... on in Wolf-Hirschhorn syndrome
@en
P2093
Dawei Jiang
Linlin Zhao
P2860
P304
P356
10.1073/PNAS.1308558110
P407
P577
2013-05-28T00:00:00Z