Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. - Wikidata - awgldk - TriplyDB

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

http://www.wikidata.org/entity/Q36932951

about

Kinases as druggable targets in trypanosomatid protozoan parasites Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3 An essential farnesylated kinesin in Trypanosoma brucei.The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.In vivo anthelmintic effect of flavonol rhamnosides from Dryopteris crassirhizoma against Dactylogyrus intermedius in goldfish (Carassius auratus).Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like libraries Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome State of the art in African trypanosome drug discovery.Development of novel drugs for human African trypanosomiasis.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Drug discovery and human African trypanosomiasis: a disease less neglected?Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.First computational chemistry multi-target model for anti-Alzheimer, anti-parasitic, anti-fungi, and anti-bacterial activity of GSK-3 inhibitors in vitro, in vivo, and in different cellular lines.Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin.Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis.Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved?

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Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

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2008 nî lūn-bûn

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Antimicrobial Agents and Chemotherapy

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Glycogen synthase kinase 3 is ...... rican trypanosomiasis therapy.

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Aaron J Riechers

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Alberto J Napuli

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Alexander Scheer

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Christophe L M J Verlinde

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Frederick S Buckner

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J Robert Gillespie

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Kayode K Ojo

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Mathias M Domostoj

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Susan J Wells

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Wesley C Van Voorhis

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P2860

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

Improved tools for biological sequence comparison.

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

Glycogen synthase kinase-3: functions in oncogenesis and development

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

Opportunities and Challenges in Antiparasitic Drug Discovery

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.

GSK3 takes centre stage more than 20 years after its discovery.

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3710-3717

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scholarly article

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10.1128/AAC.00364-08

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10

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52

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Timothy N C Wells

Michael H. Gelb

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2008-07-21T00:00:00Z

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51418884

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18644955

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African trypanosomiasis

trypanosomiasis

Lapatinib-binding protein kinase 4

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2565902

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