Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
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Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibilityReview: Gout: A Roadmap to Approaches for Improving Global OutcomesABCG2: the molecular mechanisms of urate secretion and goutIndependent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male populationGout: a review of nonmodifiable and modifiable risk factors.Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.Common variant of ALPK1 is not associated with gout: a replication study.ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout riskGenome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypesHyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2.Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.Clinical characteristics of early- and late-onset gout: A cross-sectional observational study from a Chinese gout clinic.ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility.Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics.Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette sub-family G member 2.Uric acid transporters hiding in the intestine.Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient.GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population.A comprehensive analysis of the association of common variants of ABCG2 with gout.Lumbar spinal stenosis attributable to tophaceous gout: case report and review of the literature.Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout RiskNPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.Multiple common and rare variants of ABCG2 cause gout.Functional non-synonymous variants of ABCG2 and gout risk.ABCG2 as a therapeutic target candidate for gout.ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.ABCG2 dysfunction increases the risk of renal overload hyperuricemia.The ABCG2 gene Q141K polymorphism contributes to an increased risk of gout: a meta-analysis of 2185 cases.The British Society for Rheumatology Guideline for the Management of Gout.Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia.Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese.ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion
P2860
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P2860
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
@en
type
label
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
@en
prefLabel
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
@en
P2093
P2860
P356
P1433
P1476
Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.
@en
P2093
Akiyoshi Nakayama
Asahi Hishida
Atsuyoshi Mori
Chisa Okada
Hiraku Ogata
Hiroki Inoue
Hiroshi Nakashima
Hiroshi Suzuki
Hirotaka Matsuo
Kazuki Niwa
P2860
P2888
P356
10.1038/SREP02014
P407
P577
2013-01-01T00:00:00Z
P5875
P6179
1006103959