ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. - Wikidata - awgldk - TriplyDB

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

http://www.wikidata.org/entity/Q37494208

about

Urate Handling in the Human Body The effect of angiotensin II receptor blockers on hyperuricemia Allopurinol: insights from studies of dose-response relationships.ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.Common variant of ALPK1 is not associated with gout: a replication study.ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.Intestinal Microbiota Distinguish Gout Patients from Healthy Humans The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia.A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident end-stage renal disease, and mortality Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2.Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis.Clinical characteristics of early- and late-onset gout: A cross-sectional observational study from a Chinese gout clinic.Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations.Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics.Uric acid transporters hiding in the intestine.Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient.GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.Multiple common and rare variants of ABCG2 cause gout.ABCG2 as a therapeutic target candidate for gout.Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway.Discovery and Assessment of Atropisomers of (±)-Lesinurad.Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders.Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate Decreased Serum Bilirubin Levels and Increased Uric Acid Levels are Associated with Ulcerative Colitis

P2860

Q26750896-75A5DFAE-3138-484E-93B9-33A804EC1ABB Q26777082-2FC169F5-F7E4-421D-8E1E-656E98E681A4 Q30240163-94478BF7-9995-454B-8D04-A53A42DF5ECF Q33602553-55F7DE05-713E-4D1A-BCFC-EE9216A1D09B Q33747233-B13E3F4F-2A36-4549-9B3E-6978EB8773B4 Q34677297-88EC3543-766D-4E67-9A59-C18C3698A9A9 Q34854920-4E40B359-5BD1-45B8-8CD0-47D6F65FD3E6 Q35204897-DD36B489-656D-47ED-9613-AA835C9CC8F0 Q35916817-624A317A-F589-4845-B0AF-A8182BC9BCCA Q35927066-CB6CB8B8-C326-48F2-B88C-DFC4BD26C62B Q36262189-F1ED0F78-99D3-4563-AB58-9A37BE6B655C Q36324311-CC16901B-679A-4226-B5D2-A230EBC3AD65 Q37215672-1B93BAEE-F8F0-4E47-AF09-A2A9565EA3AE Q37288330-34B2D0EB-A8B8-49A6-ADAC-3B1D85762057 Q37468214-357E0698-3841-4718-B251-17DC98814577 Q37533506-2E237EFD-5DA0-44E9-9A5D-8AA6616C393C Q37738453-33C0D297-7643-4494-B4DB-C99644D94489 Q38207943-5477BC51-6497-4364-940B-D5318B150A1E Q38827603-A637DC0E-67EB-4222-A400-599F44EE1B0E Q41082004-6C7F759D-AB0B-4778-8A81-FD83F009BD36 Q41146212-35A23A70-AAAD-46BF-AFF7-48FAD7D06DAE Q47115387-FE650C80-8DF6-4789-8DA2-8311FAA6BF52 Q47770438-6ABA7EFC-C462-4BED-BFB3-3E651C097E41 Q49258083-CF140BBC-8EC1-41AC-BA7C-65BA0640B11F Q50777594-C1185423-4BAC-4776-A72A-CE6F23FD6405 Q55080861-19B485C6-473A-4B25-8A1B-17595749B751 Q55091825-D00DD381-1AB1-46E9-9EA7-C0C6C556AFBF Q57154639-0BF1467D-9397-4E5F-B8F5-CEBCB3C78480 Q58757224-481D292D-9F5F-4A66-922E-DBBE6F767750

P2860

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

http://www.wikidata.org/entity/Q37494208

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 20 January 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@en

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@nl

type

label

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@en

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@nl

prefLabel

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@en

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@nl

P1433

Q37494208-6E98110B-6E27-4730-8BF8-2691A06EC4CD

P1476

Q37494208-88177C6E-E071-423B-B04B-C6B56CEE8DBC

P2093

Q37494208-0DB67941-26B1-4A20-9C21-6583C6075946

Q37494208-4E461197-77A3-4D88-AF2A-513DB0A0B519

Q37494208-50A2E042-6F97-4D87-9BE4-DF564474DD1B

Q37494208-56CC8254-4D0A-45DA-A5C5-3491FBAEB62B

Q37494208-5C94F712-7A09-40B6-A445-6D397268E203

Q37494208-65F37E5E-BAE9-4CC9-AB99-A19C4C0A1285

Q37494208-6C587491-CADE-49A4-B5AE-A3C674F12E90

Q37494208-7F6973AC-853C-4A37-9C54-5F81A3DE315B

Q37494208-849725C1-9F30-4A82-8282-34E089EEC6FA

Q37494208-8E42D2D6-E710-40FD-8F9E-C1CC1E5AAFBF

P2860

Q37494208-36751240-67E0-478B-BEC8-321F67A382F5

Q37494208-4EDB0194-E200-48B2-B3D4-FEA8C7533B2D

Q37494208-58292A95-FC84-47AF-B5E7-B8BFEF1BDE42

Q37494208-628CA9FE-3890-4BC3-89BA-AD709218C01F

Q37494208-6916A56A-DBC2-4213-ACA7-9ED4BB154E64

Q37494208-6BE2CF02-7F48-4D17-8C7E-48032AC45118

Q37494208-6CF82182-9F5F-4D1B-9007-2130A48342CC

Q37494208-8033AA1D-2593-472F-AB46-3B7DF8684C63

Q37494208-8DEA6FD2-5E69-41B9-BFF3-C8477F180A54

Q37494208-98BB4FE9-AD84-4B6D-87E1-AECF27A6A655

P2888

Q37494208-1F179751-8340-4127-B682-F6F444BC4BD7

P304

Q37494208-FB8F0ED6-1E39-4DDF-BE1D-C543EA14C99C

P31

Q37494208-57C2DD23-C951-45F1-B730-513986B4CCDE

P356

Q37494208-83F27814-F889-4CCC-80E5-1694BB8DFF1C

P407

Q37494208-0F65D452-04E9-4427-ABFB-B9E53EE56D6F

P478

Q37494208-F7811834-E7DE-4D65-8486-485AF6AC46C0

P50

Q37494208-786A2AB3-4D40-4C20-BC24-2756376549F1

Q37494208-BBB1E025-8A11-4AB3-AA63-39DB8ABE6839

P577

Q37494208-969E5F1A-5092-4B99-9383-A35861CA430F

P5875

Q37494208-2D5AFE7D-DB83-46DB-8984-C2CCCFB32A38

P6179

Q37494208-9768D638-C6F7-47C7-A0E7-4AC6DAC470A5

P698

Q37494208-7A9B40F8-EF17-4EDE-8D40-D530393BB559

P932

Q37494208-B86F701B-6123-462D-8C63-B1D6933DC148

P356

P1433

Scientific Reports

P1476

ABCG2 dysfunction causes hyper ...... tion and renal urate overload.

@en

P2093

Hiroki Inoue

http://www.w3.org/2001/XMLSchema#string

Hiroko Nakagawa

http://www.w3.org/2001/XMLSchema#string

Hiroshi Nakashima

http://www.w3.org/2001/XMLSchema#string

Hiroshi Suzuki

http://www.w3.org/2001/XMLSchema#string

Hirotaka Matsuo

http://www.w3.org/2001/XMLSchema#string

Junko Abe

http://www.w3.org/2001/XMLSchema#string

Kazuki Niwa

http://www.w3.org/2001/XMLSchema#string

Ken Yamamoto

http://www.w3.org/2001/XMLSchema#string

Kenji Wakai

http://www.w3.org/2001/XMLSchema#string

Kimiyoshi Ichida

http://www.w3.org/2001/XMLSchema#string

P2860

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

Molecular identification of a renal urate anion exchanger that regulates blood urate levels

Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

Homozygous SLC2A9 mutations cause severe renal hypouricemia.

Genome-wide association study of hematological and biochemical traits in a Japanese population.

Decreased extra-renal urate excretion is a common cause of hyperuricemia

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.

Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.

P2888

P304

3755

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SREP03755

http://www.w3.org/2001/XMLSchema#string

P407

P478

4

http://www.w3.org/2001/XMLSchema#string

P50

Akiyoshi Nakayama

Hirofumi Nakaoka

P577

2014-01-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

259807959

http://www.w3.org/2001/XMLSchema#string

P6179

1003207627

http://www.w3.org/2001/XMLSchema#string

P698

24441388

http://www.w3.org/2001/XMLSchema#string

P932

3895923

http://www.w3.org/2001/XMLSchema#string