The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.
about
The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionCNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretionp97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibitionTranscription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domainsThe selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expressionTALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cellsMitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD)Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cellsProteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.Redox homeostasis: The Golden Mean of healthy living.Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach.O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to HumansNrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues
P2860
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P2860
The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The membrane-topogenic vectori ...... and transactivation activity.
@en
type
label
The membrane-topogenic vectori ...... and transactivation activity.
@en
prefLabel
The membrane-topogenic vectori ...... and transactivation activity.
@en
P2860
P356
P1433
P1476
The membrane-topogenic vectori ...... and transactivation activity.
@en
P2860
P2888
P356
10.1038/SREP02006
P407
P577
2013-01-01T00:00:00Z