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The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionPhosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiationNegative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulumThe Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressorsInvolvement of the acid sphingomyelinase pathway in uva-induced apoptosisTranscription factor Nrf1 is negatively regulated by its O-GlcNAcylation statusThe Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domainsThe selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expressionTALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cellsCOOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cellsAtaxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.Nrf2- and Bach1 May Play a Role in the Modulation of Ultraviolet A-Induced Oxidative Stress by Acetyl-11-Keto-β-Boswellic Acid in Skin Keratinocytes.Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity.The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2.Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis.Requirement of ATM in UVA-induced signaling and apoptosis.Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane.Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process.NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch.Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemiaNach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to HumansNrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic TissuesOncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor RepressorDistinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genesA Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2eIF2 alpha phosphorylation alleviates UVA-induced HO-1 expression in mouse epidermal cellsNrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver CancerUnification of Opposites between Two Antioxidant Transcription Factors Nrf1 and Nrf2 in Mediating Distinct Cellular Responses to the Endoplasmic Reticulum Stressor Tunicamycin
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Yiguo Zhang
@ast
Yiguo Zhang
@en
Yiguo Zhang
@es
Yiguo Zhang
@nl
Yiguo Zhang
@sl
type
label
Yiguo Zhang
@ast
Yiguo Zhang
@en
Yiguo Zhang
@es
Yiguo Zhang
@nl
Yiguo Zhang
@sl
prefLabel
Yiguo Zhang
@ast
Yiguo Zhang
@en
Yiguo Zhang
@es
Yiguo Zhang
@nl
Yiguo Zhang
@sl
P106
P1153
7601308709
P31
P496
0000-0003-3910-2779