Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene
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Simian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factorsNo requirement for V(D)J recombination in p53-deficient thymic lymphomaSimian virus 40 large T antigen: the puzzle, the pieces, and the emerging pictureGeometry of the simian virus 40 large tumor antigen-DNA complex as probed by protease digestionTransactivation of a ribosomal gene by simian virus 40 large-T antigen requires at least three activities of the protein.A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction.The Rous sarcoma virus Env glycoprotein contains a highly conserved motif homologous to tyrosine-based endocytosis signals and displays an unusual internalization phenotypeDifferential regulation of androgen and glucocorticoid receptors by retinoblastoma protein.Enumeration of the simian virus 40 early region elements necessary for human cell transformationImpaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoA system for the analysis of BKV non-coding control regions: application to clinical isolates from an HIV/AIDS patient.Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts.Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformationT antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisSmall tumor antigen of polyomaviruses: role in viral life cycle and cell transformationSynthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral targetThe carboxy terminus of simian virus 40 large T antigen is required to disrupt the yeast cell cycleCarcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues.Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.Selection of sequence elements that substitute for the standard AATAAA motif which signals 3' processing and polyadenylation of late simian virus 40 mRNAsExpression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice.Efficient propagation of archetype BK and JC polyomaviruses.Sequential stimulation of cellular RNA synthesis in polyoma-infected mouse kidney cell cultures.The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain.Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domainMutations of the Rous sarcoma virus env gene that affect the transport and subcellular location of the glycoprotein products.Amino-terminal deletion mutants of the Rous sarcoma virus glycoprotein do not block signal peptide cleavage but can block intracellular transport.Cell surface expression of glycosylated, nonglycosylated, and truncated forms of a cytoplasmic protein pyruvate kinase.Transposition of domains between the M2 and HN viral membrane proteins results in polypeptides which can adopt more than one membrane orientationConversion of a class II integral membrane protein into a soluble and efficiently secreted protein: multiple intracellular and extracellular oligomeric and conformational forms.Microinjected pBR322 stimulates cellular DNA synthesis in Swiss 3T3 cells.Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle.A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen.Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli.The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.Simian virus 40 prevents activation of M-phase-promoting factor during lytic infection.
P2860
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P2860
Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
1983年论文
@zh
1983年论文
@zh-cn
name
Mutational analysis of simian ...... eletions in the T-antigen gene
@en
type
label
Mutational analysis of simian ...... eletions in the T-antigen gene
@en
prefLabel
Mutational analysis of simian ...... eletions in the T-antigen gene
@en
P2093
P2860
P356
P1476
Mutational analysis of simian ...... eletions in the T-antigen gene
@en
P2093
P2860
P304
P356
10.1128/MCB.3.2.203
P407
P577
1983-02-01T00:00:00Z