The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.
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The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domainA conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cellsMammalian GADD34, an apoptosis- and DNA damage-inducible geneInhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein productLeukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteinsA herpesvirus genetic element which affects translation in the absence of the viral GADD34 functionThe gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growthAn apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifsHuman BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functionsComplete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkeyHerpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complexRegulation of apoptosis by viral gene productsSelective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34.5 null mutants in primary human CNS tumours--evaluation of a potentially effective clinical therapyAssociation of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptidesOncolytic virus therapy: A new era of cancer treatment at dawnOncolytic virotherapy using herpes simplex virus: how far have we come?A herpes simplex virus-derived replicative vector expressing LIF limits experimental demyelinating disease and modulates autoimmunityAn African swine fever virus virulence-associated gene NL-S with similarity to the herpes simplex virus ICP34.5 geneThe human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activityHerpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells.A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cellsInduction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer.Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future PerspectivesMechanisms of viral pathogenesis in rheumatic diseaseHerpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.Regulation of translation initiation following stress.Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herThe second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alphaThe herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha.A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animalsToxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma.Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK)The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.
P2860
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P2860
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
The gamma 1(34.5) gene of herp ...... cell death in neuronal cells.
@en
type
label
The gamma 1(34.5) gene of herp ...... cell death in neuronal cells.
@en
prefLabel
The gamma 1(34.5) gene of herp ...... cell death in neuronal cells.
@en
P2860
P356
P1476
The gamma 1(34.5) gene of herp ...... cell death in neuronal cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.8.3266
P407
P577
1992-04-01T00:00:00Z