Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage.
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BK channels: multiple sensors, one activation gateStructural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domainAlternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levelsA linkage analysis toolkit for studying allosteric networks in ion channels.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Cryo-EM structure of the open high-conductance Ca2+-activated K+ channelAn epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangementsBK channel activation: structural and functional insightsIon sensing in the RCK1 domain of BK channels.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelLarge conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signalingModulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedThe contribution of RCK domains to human BK channel allosteric activationBarium ions selectively activate BK channels via the Ca2+-bowl siteRelative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.Free-energy relationships in ion channels activated by voltage and ligand.State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channelsMeasuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel.Transduction of voltage and Ca2+ signals by Slo1 BK channels.Alcohol modulation of BK channel gating depends on β subunit compositionInteractions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ringAllosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel.BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.Regulation of BK channels by auxiliary γ subunits.Molecular Determinants of BK Channel Functional Diversity and Functioning.Understanding the conformational motions of RCK gating rings.Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels.Structural basis for gating the high-conductance Ca2+-activated K+ channel.Allosteric control of gating mechanisms revisited: the large conductance Ca2+-activated K+ channel.Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channelsPresynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications.Large-conductance Ca2+ -activated K+ channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium.Return of the electric binding site.Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.Molecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring.
P2860
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P2860
Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Measurements of the BKCa chann ...... : effects of membrane voltage.
@en
type
label
Measurements of the BKCa chann ...... : effects of membrane voltage.
@en
prefLabel
Measurements of the BKCa chann ...... : effects of membrane voltage.
@en
P2860
P356
P1476
Measurements of the BKCa chann ...... : effects of membrane voltage.
@en
P2093
Daniel H Cox
Tara-Beth Sweet
P2860
P304
P356
10.1085/JGP.200810094
P577
2008-11-01T00:00:00Z