Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
about
Gating mechanism of BK (Slo1) channels: so near, yet so farThe RCK2 domain of the human BKCa channel is a calcium sensorStructural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channelMotifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensingBilayer reconstitution of voltage-dependent ion channels using a microfabricated silicon chip.A BK (Slo1) channel journey from molecule to physiology.Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelSetting the stage for molecular dissection of the regulatory components of BK channels.Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedThe LRRC26 protein selectively alters the efficacy of BK channel activators.Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and bariumThe contribution of RCK domains to human BK channel allosteric activationRelative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsRole of charged residues in the S1-S4 voltage sensor of BK channels.Intra- and intersubunit cooperativity in activation of BK channels by Ca2+Modes of operation of the BKCa channel beta2 subunit.Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Differential effects of beta 1 and beta 2 subunits on BK channel activity.Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.Oxidative regulation of large conductance calcium-activated potassium channels.Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels.Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channelsVoltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism.Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effectGating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanismAllosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism.Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation siteIntracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels.Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity is enhanced by its beta1 subunit
P2860
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P2860
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@ast
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@en
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@nl
type
label
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@ast
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@en
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@nl
prefLabel
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@ast
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@en
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@nl
P2093
P2860
P356
P1476
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
@en
P2093
P2860
P304
P356
10.1074/JBC.273.49.32430
P407
P577
1998-12-04T00:00:00Z