hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
about
A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsCanine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and TreatmentMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainThe S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingStructural imperatives impose diverse evolutionary constraints on helical membrane proteinsCombined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family.Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore openingProline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channelConcerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsMolecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsMutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasConservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling.Cardiac slices as a predictive tool for arrhythmogenic potential of drugs and chemicals.Cytoplasmic domains and voltage-dependent potassium channel gating.Voltage-dependent gating of HERG potassium channels.Mechanism of electromechanical coupling in voltage-gated potassium channels.The enigmatic cytoplasmic regions of KCNH channels.De novo KCNH1 mutations in four patients with syndromic developmental delay, hypotonia and seizures.Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer.Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels.Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains.Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.The evolutionarily conserved residue A653 plays a key role in HERG channel closing.
P2860
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P2860
hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
@en
type
label
hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
@en
prefLabel
hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
@en
P2860
P356
P1476
hERG gating microdomains defined by S6 mutagenesis and molecular modeling
@en
P2093
Anne Lynn Gillian-Daniel
Gail A Robertson
P2860
P304
P356
10.1085/JGP.200810083
P577
2008-11-01T00:00:00Z