Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
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Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine IntegrationGNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognitionGs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling[EXPRESS] Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats.Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein InteractionsOptogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator.Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.Thermodynamics of GPCR activation.The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.The Multiple Waves of Cannabinoid 1 Receptor Signaling.Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis.RGS14 regulates the lifetime of Gα-GTP signaling but does not prolong Gβγ signaling following receptor activation in live cells.G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.Discovery of new GPCR ligands to illuminate new biology.Pharmacogenomics of GPCR Drug Targets.Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A.Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.Trends in GPCR drug discovery: new agents, targets and indications.Rapid kinetic BRET measurements to monitor G protein activation by GPCR and non-GPCR proteins.Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function Gα11 Mutation.RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling.Selectivity determinants of GPCR-G-protein binding.Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.Making useful gadgets with miniaturized G proteins.Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteinsCryo-EM structure of the serotonin 5-HT receptor coupled to heterotrimeric G
P2860
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P2860
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Distinct profiles of functiona ...... f G protein-coupled receptors.
@en
type
label
Distinct profiles of functiona ...... f G protein-coupled receptors.
@en
prefLabel
Distinct profiles of functiona ...... f G protein-coupled receptors.
@en
P2093
P2860
P1433
P1476
Distinct profiles of functiona ...... f G protein-coupled receptors.
@en
P2093
Christopher D Jones
Grant M Kramer
Ikuo Masuho
Keqiang Xie
Kirill A Martemyanov
Olga Ostrovskaya
P2860
P356
10.1126/SCISIGNAL.AAB4068
P577
2015-12-01T00:00:00Z