Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.
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NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesSynthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp9019-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.Protein chaperones: a composition of matter review (2008 - 2013).A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans.Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes.A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.Conformation-activity relationships of polyketide natural products.Hsp90 molecular chaperone inhibitors: are we there yet?A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases.A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.HSP90 affects the stability of BMAL1 and circadian gene expression.An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2.Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.Protective effect of thymoquinone against lead-induced hepatic toxicity in rats.
P2860
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P2860
Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Enzymatic reduction and glutat ...... icity and mechanism of action.
@en
type
label
Enzymatic reduction and glutat ...... icity and mechanism of action.
@en
prefLabel
Enzymatic reduction and glutat ...... icity and mechanism of action.
@en
P2093
P2860
P356
P1476
Enzymatic reduction and glutat ...... icity and mechanism of action.
@en
P2093
David Ross
David Siegel
Philip Reigan
Wenchang Guo
P2860
P304
P356
10.1124/DMD.108.022004
P577
2008-07-17T00:00:00Z