Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors
about
Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical AppraisalTherapeutic approaches in myelofibrosis and myelodysplastic/myeloproliferative overlap syndromesAberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceAdvanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitorsThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseExploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunitiesNovel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinomaDYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistanceEMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaPancreatic cancer and its stroma: a conspiracy theoryChallenges and new horizons in the management of advanced basal cell carcinoma: a UK perspective.Disrupting the balance between tumor epithelia and stroma is a possible therapeutic approach for pancreatic cancer.Challenges and future directions in therapeutics for pancreatic ductal adenocarcinoma.Tackling the cancer stem cells - what challenges do they pose?Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer.Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer.Targeting cancer stem cells in solid tumors by vitamin D.Advances in the management of basal cell carcinoma.Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.LncRNA BCAR4 wires up signaling transduction in breast cancer.The Hedgehog pathway as targetable vulnerability with 5-azacytidine in myelodysplastic syndrome and acute myeloid leukemiaInhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication.Hedgehog signaling and radiation induced liver injury: a delicate balance.Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosisRecent advances and future of immunotherapy for glioblastoma.Targeting hedgehog signaling in myelofibrosis and other hematologic malignanciesNovel treatments for head and neck squamous cell carcinoma: preclinical identification and clinical investigation.Targeted treatment for sonic hedgehog-dependent medulloblastoma.Phase I trial of the oral smoothened inhibitor sonidegib in combination with paclitaxel in patients with advanced solid tumors.Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication.SHH inhibitors for the treatment of medulloblastoma.Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.Non-melanoma skin cancer: new and future synthetic drug treatments.Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma.
P2860
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P2860
Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Phase I study of the Hedgehog ...... ult patients with solid tumors
@en
type
label
Phase I study of the Hedgehog ...... ult patients with solid tumors
@en
prefLabel
Phase I study of the Hedgehog ...... ult patients with solid tumors
@en
P2093
P2860
P1476
Phase I study of the Hedgehog ...... ult patients with solid tumors
@en
P2093
Anne Lynne S Chang
Antonio Jimeno
Georgios Skliris
Glen J Weiss
Jeff Kutok
Joi Dunbar
Karl D Lewis
Kerrie Faia
Raoul Tibes
Robert W Ross
P2860
P304
P356
10.1158/1078-0432.CCR-12-3654
P407
P577
2013-04-10T00:00:00Z