Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosolMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisEvidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAXStructural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisStructural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteinsNovel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process.Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions.The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion proteinVariations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins.Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membraneEnhanced antitumor effects of BPD-MA-mediated photodynamic therapy combined with adriamycin on breast cancer in miceBax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic functionZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cellsConformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax proteinDeerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.Intertwined pathways of programmed cell death in immunity.Identification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neuronsTranslocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.Bax dimerizes via a symmetric BH3:groove interface during apoptosisHuman Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.Apoptosis is induced in cancer cells via the mitochondrial pathway by the novel xylocydine-derived compound JRS-15.miR-150 inhibits terminal erythroid proliferation and differentiation.Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.Yeast techniques for modeling drugs targeting Bcl-2 and caspase family members.Physiological restraint of Bak by Bcl-xL is essential for cell survival.Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.Structural biology of the Bcl-2 family and its mimicry by viral proteinsControl of mitochondrial apoptosis by the Bcl-2 family.The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.
P2860
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P2860
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
@en
type
label
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
@en
prefLabel
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
@en
P2860
P50
P356
P1476
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
@en
P2093
Jamie I Fletcher
Sarina Meusburger
P2860
P304
18081-18087
P356
10.1073/PNAS.0808691105
P407
P577
2008-11-03T00:00:00Z