A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
about
Modulation of pancreatic exocrine and endocrine secretionTLQP-21 protects human umbilical vein endothelial cells against high-glucose-induced apoptosis by increasing G6PD expressionNkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptorsOpposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional miceHuman β-cell regeneration: progress, hurdles, and controversy.The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivityActivated FoxM1 attenuates streptozotocin-mediated β-cell death.The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanismRole of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF.VGF Peptide Profiles in Type 2 Diabetic Patients' Plasma and in Obese Mice.Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in MiceArgonaute2 regulates the pancreatic β-cell secretome.Inactivation of specific β cell transcription factors in type 2 diabetes.Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cellsPdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis.The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO CellsThe regulation of pre- and post-maturational plasticity of mammalian islet cell mass.New factors secreted from islets expand β-cell massEmbryonic ablation of neuronal VGF increases energy expenditure and reduces body weight.The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cellsNkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos.Exploring new routes for secretory protein export from the trans-Golgi network.Physiological mechanisms of sustained fumagillin-induced weight loss.
P2860
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P2860
A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A VGF-derived peptide attenuat ...... β-cell survival and function.
@en
type
label
A VGF-derived peptide attenuat ...... β-cell survival and function.
@en
prefLabel
A VGF-derived peptide attenuat ...... β-cell survival and function.
@en
P2093
P2860
P50
P1433
P1476
A VGF-derived peptide attenuat ...... t β-cell survival and function
@en
P2093
Albert Y Sun
Christopher B Newgard
Hans E Hohmeier
P2860
P356
10.1016/J.CMET.2012.05.011
P577
2012-07-01T00:00:00Z