Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.
about
Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cellsSON controls cell-cycle progression by coordinated regulation of RNA splicingStructure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activitySON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 clusterCBFbeta is critical for AML1-ETO and TEL-AML1 activity.Son is essential for nuclear speckle organization and cell cycle progression.Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chainThe role of SON in splicing, development, and diseaseGenetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila modelSON is a spliceosome-associated factor required for mitotic progression.Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.Identification of small molecule inhibitors of pre-mRNA splicing.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingSon maintains accurate splicing for a subset of human pre-mRNAs.Overexpression and knockout of miR-126 both promote leukemogenesisRUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.RUNX1-ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development.Pre-mRNA splicing in disease and therapeutics.New discoveries of old SON: a link between RNA splicing and cancer.Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.NHR4 domain mutations of ETO are probably very infrequent in AML1-ETO positive myeloid leukemia cells.
P2860
Q21245757-12F877DA-C2B0-4FA0-9F60-E7606AB317B5Q24299993-B778273A-1933-4283-B6EB-C9D19651FBDEQ27664050-536BE5C3-E5D4-41A0-BCA6-4CD8163B4B9EQ28283462-D0A6B0B3-955B-4BD3-9273-C5099CFE2C73Q30439864-E9A6A1E7-461A-4585-89CD-66077AA470BAQ30493098-B475ABEC-5016-4BC9-A4EB-FB6803B182DDQ33479917-69642F5D-EC49-4376-8C2B-2FE899345B42Q33861176-39056215-E88A-43F6-90E8-49EB5D68AD88Q34066845-C61ABF00-9537-47A4-9FBF-2106542A2AB0Q34374087-AAD496B3-6F6D-4FF3-9A42-9F2B80159842Q34581827-4CAF8167-A996-49A7-8879-EC0AA8DAB011Q34648630-0024AD91-F37F-4882-9F0A-DC498B8ABD83Q35301222-6CE04C36-4C9C-4C8C-BEDC-334DA3441CF2Q35642451-9375FBDE-D44E-4F9A-B16F-9498E6A953ACQ35672134-D880E2B9-E09B-4A29-978F-36EFE30AB127Q36193187-A998C0FC-CF9C-4B70-A247-168129E8C03CQ36206674-9BCC4FA4-ED63-4807-AFF0-DA47D028FFF1Q37621927-B76F0955-80B9-4F43-A553-2D4512E29147Q37679748-C9C735C6-81F6-477E-B5DD-2322361936F6Q37704367-2DC3B9E1-9D14-4757-B6F0-40D6EDE3F9A5Q38028093-43AA08C4-964E-4A7C-9097-0D86B16400CCQ39351268-B46646A1-0A4B-4D2E-9B97-5DE3F3C7D7D5Q41973082-9E2DF88C-2C0A-4CC9-B281-61EA709AC98EQ42049385-1080386C-B44D-4916-A45B-D350D58585F5Q47127883-F50ABB77-29A8-4BDE-9E68-50F7396A8A85Q54445454-89E0881D-0E01-4C6C-933D-D5388CCA7E47
P2860
Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Disruption of the NHR4 domain ...... g and promotes leukemogenesis.
@en
type
label
Disruption of the NHR4 domain ...... g and promotes leukemogenesis.
@en
prefLabel
Disruption of the NHR4 domain ...... g and promotes leukemogenesis.
@en
P2093
P2860
P356
P1476
Disruption of the NHR4 domain ...... g and promotes leukemogenesis.
@en
P2093
Anita Boyapati
Dong-Er Zhang
Eun-Young Ahn
Miao-Chia Lo
Oxana A Malakhova
Robert Hines
P2860
P304
17103-17108
P356
10.1073/PNAS.0802696105
P407
P577
2008-10-24T00:00:00Z