BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. - Wikidata - awgldk - TriplyDB

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

http://www.wikidata.org/entity/Q36967843

about

Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Emerging roles of extracellular vesicles in the nervous system Proteomic Substrate Identification for Membrane Proteases in the Brain PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation A tale of two drug targets: the evolutionary history of BACE1 and BACE2 Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in Fonsecaea pedrosoi.The refractive state of the eye in Icelandic horses with the Silver mutation.Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Targeting the β secretase BACE1 for Alzheimer's disease therapy.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.Melanosomal formation of PMEL core amyloid is driven by aromatic residues.Amyloid-based nanosensors and nanodevices.BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.Effects of microRNA-136 on melanoma cell proliferation, apoptosis, and epithelial-mesenchymal transition by targetting PMEL through the Wnt signaling pathway.On the evolutionary trajectories of signal-transducing amyloids in fungi and beyond.Amyloids, melanins and oxidative stress in melanomagenesis.Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.Why are Functional Amyloids Non-Toxic in Humans?Meeting after meeting: 20 years of discoveries by the members of the Exocytosis-Endocytosis Club.Expression of skin color genes in lymphocytes of Karan Fries cattle and seasonal relationship with tyrosinase and cortisol.Mechanical properties of amyloid-like fibrils defined by secondary structures.Analyzing Lysosome-Related Organelles by Electron Microscopy.Amyloid assembly and disassembly Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles

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P2860

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

http://www.wikidata.org/entity/Q36967843

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

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type

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BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

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prefLabel

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

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PNAS.1220748110

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Proceedings of the National Academy of Sciences of the United States of America

P1476

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

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Brenda Watt

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Cecile Fort

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Graça Raposo

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Ilse Hurbain

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Leila Rochin

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Lutgarde Serneels

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Michael S Marks

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Pascal Leblanc

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P2860

Functional amyloid formation within mammalian tissue.

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

Melanosomes--dark organelles enlighten endosomal membrane transport

Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells

ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties

Computer visualization of three-dimensional image data using IMOD

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

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10658-10663

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scholarly article

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10.1073/PNAS.1220748110

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26

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110

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Guillaume van Niel

Bart De Strooper

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2013-06-10T00:00:00Z

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23754390

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3696817

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