MICE models: superior to the HERG model in predicting Torsade de Pointes.
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Recent developments in using mechanistic cardiac modelling for drug safety evaluationScreening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator.Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activatorsPrediction of Thorough QT study results using action potential simulations based on ion channel screensPredicting QTc Prolongation in Man From Only In Vitro Data.Systems Toxicology: Real World Applications and Opportunities.Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug.The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine.Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information.A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment.Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamilA web portal for in-silico action potential predictionsQT prolongation and torsades de pointes with psychotropic agentsQuantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.New potential binding determinant for hERG channel inhibitors.Human Engineered Heart Tissue: Analysis of Contractile ForceA new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.Cardiac action potential repolarization re-visited: early repolarization shows all-or-none behaviour.A 2015 focus on preventing drug-induced arrhythmias.Natural products modulating the hERG channel: heartaches and hope.Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections.L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier.Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening.Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment.Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability.Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk AssessmentCorrelation between human ether-a-go-go-related gene channel inhibition and action potential prolongation.Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic CardiotoxicityMechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.Early Drug Discovery Prediction of Proarrhythmia Potential and Its CovariatesAn Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived CardiomyocytesComputational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles.Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features.Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms.Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform.
P2860
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P2860
MICE models: superior to the HERG model in predicting Torsade de Pointes.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
MICE models: superior to the HERG model in predicting Torsade de Pointes.
@en
type
label
MICE models: superior to the HERG model in predicting Torsade de Pointes.
@en
prefLabel
MICE models: superior to the HERG model in predicting Torsade de Pointes.
@en
P2093
P2860
P356
P1433
P1476
MICE models: superior to the HERG model in predicting Torsade de Pointes.
@en
P2093
Andrew Bruening-Wright
Arthur M Brown
Carlos A Obejero-Paz
James Kramer
Joseph S Verducci
Yuri A Kuryshev
P2860
P2888
P356
10.1038/SREP02100
P407
P50
P577
2013-01-01T00:00:00Z