Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
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Parkinson's disease: gene therapiesEnhanced nigrostriatal neuron-specific, long-term expression by using neural-specific promoters in combination with targeted gene transfer by modified helper virus-free HSV-1 vector particles.Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the UL13 protein kinase and specific components of the VP16 transcriptional complex.Use of the 2A peptide for generation of multi-transgenic pigs through a single round of nuclear transfer.Gene therapy progress and prospects: Parkinson's disease.Herpes simplex virus-based vectors.HSV-1-based amplicon vectors: design and applications.Subthalamic hGAD65 gene therapy and striatum TH gene transfer in a Parkinson's disease rat model.HSV-1 amplicon vectors: a promising and versatile tool for gene delivery.Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease.Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioraViral vectors for gene delivery to the central nervous system.Antibody-mediated targeted gene transfer of helper virus-free HSV-1 vectors to rat neocortical neurons that contain either NMDA receptor 2B or 2A subunits.A 16 bp upstream sequence from the rat tyrosine hydroxylase promoter supports long-term expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system.The vesicular glutamate transporter-1 upstream promoter and first intron each support glutamatergic-specific expression in rat postrhinal cortex.Antibody-mediated targeted gene transfer to NMDA NR1-containing neurons in rat neocortex by helper virus-free HSV-1 vector particles containing a chimeric HSV-1 glycoprotein C-staphylococcus A proteinImmobilized cobalt affinity chromatography provides a novel, efficient method for herpes simplex virus type 1 gene vector purification.Herpes Virus Amplicon Vectors.Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter.Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system.A helper virus-free HSV-1 vector containing the vesicular glutamate transporter-1 promoter supports expression preferentially in VGLUT1-containing glutamatergic neurons.Overexpression of either lysine-specific demethylase-1 or CLOCK, but not Co-Rest, improves long-term expression from a modified neurofilament promoter, in a helper virus-free HSV-1 vector systemImproved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons.Understanding and prevention of "therapy-" induced dyskinesias.Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOILong-term transgene expression in mouse neural progenitor cells modified with phiC31 integrase.Long-term inducible expression in striatal neurons from helper virus-free HSV-1 vectors that contain the tetracycline-inducible promoter system.And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation.Gene Therapy for Parkinson's Disease, An Update.In vivo methods for acute modulation of gene expression in the central nervous system
P2860
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P2860
Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Correction of a rat model of P ...... es simplex virus type 1 vector
@en
type
label
Correction of a rat model of P ...... es simplex virus type 1 vector
@en
prefLabel
Correction of a rat model of P ...... es simplex virus type 1 vector
@en
P2093
P2860
P1433
P1476
Correction of a rat model of P ...... es simplex virus type 1 vector
@en
P2093
Alfred I Geller
Courtney Holmes
David S Goldstein
Guo-Rong Zhang
Lingxin Kong
Xiaodan Wang
P2860
P304
P356
10.1089/104303403321467180
P577
2003-03-01T00:00:00Z