A chemical and genetic approach to the mode of action of fumagillin
about
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentinPyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsZebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plantsEvaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvaeAcaricide, fungicide and drug interactions in honey bees (Apis mellifera)Regulated tissue fluidity steers zebrafish body elongation.Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeuticsA selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis.Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides.An array of bengamide E analogues modified at the terminal olefinic position: synthesis and antitumor properties.Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo.Rescue effects: irradiated cells helped by unirradiated bystander cellsDisruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.From phenotype to mechanism after zebrafish small molecule screens.Small zebrafish in a big chemical pond.Targeting Wnt pathways in disease.Small-molecule modulators of Hh and Wnt signaling pathways.Natural products: chemical instruments to apprehend biological symphony.Involution of collagen-induced arthritis with an angiogenesis inhibitor, PPI-2458.Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons.The relationship between early embryo development and tumourigenesis.MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.Planar cell polarity signaling in collective cell movements during morphogenesis and disease.Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidasesZebrafish as tools for drug discovery.Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry.Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancerWhen it is hard to get to with genetics--planar cell polarity under a chemical scalpel.A role for planar cell polarity signaling in angiogenesis.Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles.Methionine aminopeptidase 2 is required for HSC initiation and proliferation.Cotranslational proteolysis dominates glutathione homeostasis to support proper growth and development.Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice.
P2860
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P2860
A chemical and genetic approach to the mode of action of fumagillin
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A chemical and genetic approach to the mode of action of fumagillin
@en
type
label
A chemical and genetic approach to the mode of action of fumagillin
@en
prefLabel
A chemical and genetic approach to the mode of action of fumagillin
@en
P2093
P2860
P1476
A chemical and genetic approach to the mode of action of fumagillin
@en
P2093
Andrew Mara
Craig M Crews
Hilary L Griesbach
Jing Ruey Yeh
John F Hines
Pasquale Cirone
Scott A Holley
P2860
P304
P356
10.1016/J.CHEMBIOL.2006.07.010
P577
2006-09-01T00:00:00Z