Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
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The effects of TLR activation on T-cell development and differentiationTargeting the Fc receptor in autoimmune diseaseLoss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCsThe tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionCD14 controls the LPS-induced endocytosis of Toll-like receptor 4DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance.Selective antibody intervention of Toll-like receptor 4 activation through Fc γ receptor tethering.ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.Mediators of Tyrosine Phosphorylation in Innate Immunity: From Host Defense to Inflammation onto Oncogenesis.The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation.DAP12 promotes IRAK-M expression and IL-10 production by liver myeloid dendritic cells and restrains their T cell allostimulatory ability.A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways.TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer.DAP10- and DAP12-associated receptors in innate immunity.Cross-regulation of signaling by ITAM-associated receptors.Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.Molecular mechanisms of regulation of Toll-like receptor signalingTREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells.β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation.FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.The anti-lymphoma activities of anti-CD137 monoclonal antibodies are enhanced in FcγRIII(-/-) mice.A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells.
P2860
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P2860
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Increased TLR responses in den ...... g adapters DAP12 and FcRgamma.
@en
type
label
Increased TLR responses in den ...... g adapters DAP12 and FcRgamma.
@en
prefLabel
Increased TLR responses in den ...... g adapters DAP12 and FcRgamma.
@en
P2093
P2860
P356
P1476
Increased TLR responses in den ...... g adapters DAP12 and FcRgamma.
@en
P2093
Ching-Liang Chu
Clifford A Lowell
Jessica A Hamerman
Kuan-Yin Shen
Lewis L Lanier
Yen-Ling Yu
P2860
P304
P356
10.1002/EJI.200737600
P407
P577
2008-01-01T00:00:00Z