Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. - Wikidata - awgldk - TriplyDB

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

http://www.wikidata.org/entity/Q36990484

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Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation Peptidylarginine deiminase and protein citrullination in prion diseases: strong evidence of neurodegeneration Potential role for PAD2 in gene regulation in breast cancer cells.Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones.Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains.Chemical biology of protein arginine modifications in epigenetic regulation Adhesion and hemifusion of cytoplasmic myelin lipid membranes are highly dependent on the lipid composition.Protein Citrullination: A Proposed Mechanism for Pathology in Traumatic Brain Injury.Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis.Detection and identification of protein citrullination in complex biological systems Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway.Fuzzy complexes of myelin basic protein: NMR spectroscopic investigations of a polymorphic organizational linker of the central nervous system.Epigenetics of multiple sclerosis: an updated review.Unconventional post-translational modifications in immunological signaling.Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis.Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology.PAD2 Activity Monitored via a Fluorescent Substrate Analog.Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?Increased expression of PAD2 after repeated intracerebroventricular infusions of soluble Abeta(25-35) in the Alzheimer's disease model rat brain: effect of memantine.Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline.And Yet it is Modified-Holding a Candle to the Dark Matter of White Matter.Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood.Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development

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Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

http://www.wikidata.org/entity/Q36990484

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Abdiwahab A Musse

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Cameron A Ackerley

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Dorothee Bienzle

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Fabrizio G Mastronardi

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Helena Lei

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Mario A Moscarello

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Roberto Poma

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Zhen Li

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The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis

Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

A tale of two citrullines--structural and functional aspects of myelin basic protein deimination in health and disease

Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis

Isolation and molecular cloning of epidermal- and hair follicle-specific peptidylarginine deiminase (type III) from rat

Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis.

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

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