Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
about
Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive responseGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesThe role of aberrant proteolysis in lymphomagenesisCyclin D as a therapeutic target in cancerLysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradationThe Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformationDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.F-box proteins FBXO31 and FBX4 in regulation of cyclin D1 degradation upon DNA damage.C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expressionFunctional characterization of breast cancer using pathway profilesA function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.SCF ubiquitin ligases in the maintenance of genome stability.Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer.PP2A(Cdc55) regulates G1 cyclin stability.Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks.Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degronAcquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle.CRL Ubiquitin Ligases and DNA Damage Response.Proteomic identification of a direct role for cyclin d1 in DNA damage repair.Cyclin D type does not influence cell cycle response to DNA damage caused by ionizing radiation in multiple myeloma tumours.Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation.Cyclin D1, cancer progression, and opportunities in cancer treatment.Targeting the AKT/cyclin D1 pathway to overcome intrinsic and acquired radioresistance of tumors for effective radiotherapy.ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.DNA damage-dependent cyclin D1 proteolysis: GSK3beta holds the smoking gunTargeting the RB-pathway in cancer therapy.Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.Cyclin D3: To translate or not to translate.CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression.
P2860
Q27014767-B495EAAB-B65B-4FF6-B6B2-952223595EE9Q27027897-F01C043C-84AB-4C29-B68A-5BBB4A916E6EQ28084404-001A7953-DED6-452E-B695-3879C2F22C98Q28242623-6E01CFDC-6574-4846-81C3-C4257E44ABF2Q28508267-C782A32A-4F5C-4F68-9606-F9DB80D5E425Q28592198-32D7106C-8F67-4F82-BA93-AF8B8B266255Q30278581-FB1EAA12-AE39-46FE-8963-FB3147932935Q33856507-7EA1F0FA-1B91-4C21-A746-DB9E7AD7ABCFQ33904055-8D5CB443-23A4-4AF0-A826-44E7F9378D0EQ33927425-976AAC64-9083-4FC2-8F21-1287E0AEEFB5Q33962784-B69F54D0-9239-4014-9D94-3CFAD5674791Q35099578-2DAB0657-2234-42B2-8B45-5497DF292E8AQ35575742-53373DEF-1EA2-40C0-92E1-465A70218B04Q35697802-EC344F27-A264-4EA0-A981-6738C5833440Q35754115-84FEBBA6-007F-43EF-919F-E49F55405401Q36385701-11F75026-D3A9-444F-9C93-1BEA825AB138Q36906235-ED125D5C-A343-48CD-A060-668D2EC192B0Q37409394-7394B7B0-29CA-4ACB-8103-DFC963A07246Q37725290-9F5733B6-6A84-4A04-B00D-7100E0716C7EQ37924479-BBA4AF39-87AC-4BFF-A73B-C06545F7FBA1Q38015388-A0498E2F-0A73-436D-AA25-F4E84FEC947FQ38037046-EB737DD2-9431-4F66-ADA5-50A25A7EB389Q38773174-129405B8-BDD1-421D-9128-67851F3D28F9Q38834030-EA1B7D98-A151-48D9-BE28-9D4572DB6B82Q38970431-3F07A190-0C82-41CA-9C46-71E8D5663124Q39026867-D2AFDCE8-31E8-4505-8CDC-58FDCFBCAC85Q41893268-DF9063D9-337D-41E9-AA28-897CEB704F2AQ41989448-B7C4D9BC-763B-405D-B832-F234C3923963Q42021453-E99A79B6-B77D-4426-905E-B0F629564299Q42327801-01DD9CCF-9902-41D8-AA9B-6740E38DD131Q42359641-E3AA61C1-2550-4F94-8114-54B22E5525ABQ50959185-780D5EAC-00D0-4DC0-ACFB-7738BE351EF7
P2860
Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Genotoxic stress-induced cycli ...... required for genomic stability
@en
type
label
Genotoxic stress-induced cycli ...... required for genomic stability
@en
prefLabel
Genotoxic stress-induced cycli ...... required for genomic stability
@en
P2093
P2860
P356
P1476
Genotoxic stress-induced cycli ...... required for genomic stability
@en
P2093
Craig H Bassing
Eric J Brown
J Alan Diehl
Laura L Pontano
Olena Barbash
Priya Aggarwal
P2860
P304
P356
10.1128/MCB.01085-08
P407
P577
2008-09-22T00:00:00Z