The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.
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M2 protein from influenza A: from multiple structures to biophysical and functional insightsViral Membrane Channels: Role and Function in the Virus Life CycleStructural basis for the function and inhibition of an influenza virus proton channelStructure of the amantadine binding site of influenza M2 proton channels in lipid bilayersStructure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virusStructure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virusFlipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface.Assembly of the m2 tetramer is strongly modulated by lipid chain length.Structural basis for proton conduction and inhibition by the influenza M2 protein.Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.Conformational heterogeneity of the M2 proton channel and a structural model for channel activationCoexistence of two adamantane binding sites in the influenza A M2 ion channel.Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virusThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesMultiple Proton Confinement in the M2 Channel from the Influenza A VirusViral miniproteinsSolid-supported membrane technology for the investigation of the influenza A virus M2 channel activityThe strong dimerization of the transmembrane domain of the fibroblast growth factor receptor (FGFR) is modulated by C-terminal juxtamembrane residues.Identification of the functional core of the influenza A virus A/M2 proton-selective ion channelAcid activation mechanism of the influenza A M2 proton channel.Structure and function of the influenza A M2 proton channelStructural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virusConformational plasticity of the influenza A M2 transmembrane helix in lipid bilayers under varying pH, drug binding, and membrane thickness.The Molecular Switch of Telomere Phages: High Binding Specificity of the PY54 Cro Lytic Repressor to a Single Operator Site.Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy.Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein.Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers.
P2860
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P2860
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The interplay of functional tu ...... el from the influenza A virus.
@en
type
label
The interplay of functional tu ...... el from the influenza A virus.
@en
prefLabel
The interplay of functional tu ...... el from the influenza A virus.
@en
P2093
P2860
P1433
P1476
The interplay of functional tu ...... el from the influenza A virus.
@en
P2093
Amanda L Stouffer
Chunlong Ma
James D Lear
Lawrence H Pinto
Lidia Cristian
Robert A Lamb
Yuki Ohigashi
P2860
P304
P356
10.1016/J.STR.2008.04.011
P577
2008-07-01T00:00:00Z